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- W2118521160 endingPage "983" @default.
- W2118521160 startingPage "983" @default.
- W2118521160 abstract "The brain processes sensory information in neuronal networks that are shaped by experience, particularly during early life, to optimally represent the internal and external milieu. Recent surprising findings have revealed that antidepressant drugs reactivate a window of juvenile-like plasticity in the adult cortex. When antidepressant-induced plasticity was combined with appropriate rehabilitation, it brought about a functional recovery of abnormally wired neuronal networks. These observations suggest that antidepressants act permissively to facilitate environmental influence on neuronal network reorganization and so provide a plausible neurobiological explanation for the enhanced effect of combining antidepressant treatment with psychotherapy. The results emphasize that pharmacological and psychological treatments of mood disorders are closely entwined: the effect of antidepressant-induced plasticity is facilitated by rehabilitation, such as psychotherapy, that guides the plastic networks, and psychotherapy benefits from the enhanced plasticity provided by the drug treatment. Optimized combinations of pharmacological and psychological treatments might help make best use of existing antidepressant drugs and reduce the number of treatment-resistant patients. The network hypothesis of antidepressant action presented here proposes that recovery from depression and related mood disorders is a gradual process that develops slowly and is facilitated by structured guidance and rehabilitation." @default.
- W2118521160 created "2016-06-24" @default.
- W2118521160 creator A5019744869 @default.
- W2118521160 date "2013-09-01" @default.
- W2118521160 modified "2023-10-14" @default.
- W2118521160 title "Neuronal Network Plasticity and Recovery From Depression" @default.
- W2118521160 cites W1509868652 @default.
- W2118521160 cites W1523136835 @default.
- W2118521160 cites W1538662170 @default.
- W2118521160 cites W1572640432 @default.
- W2118521160 cites W1599432679 @default.
- W2118521160 cites W1815206142 @default.
- W2118521160 cites W1963806203 @default.
- W2118521160 cites W1967017538 @default.
- W2118521160 cites W1972954672 @default.
- W2118521160 cites W1974004848 @default.
- W2118521160 cites W1978415644 @default.
- W2118521160 cites W1980708963 @default.
- W2118521160 cites W1981220245 @default.
- W2118521160 cites W1985237413 @default.
- W2118521160 cites W1988993555 @default.
- W2118521160 cites W1989385052 @default.
- W2118521160 cites W1991830040 @default.
- W2118521160 cites W1993217952 @default.
- W2118521160 cites W1999628548 @default.
- W2118521160 cites W2001567401 @default.
- W2118521160 cites W2003736729 @default.
- W2118521160 cites W2004762037 @default.
- W2118521160 cites W2010269783 @default.
- W2118521160 cites W2011200277 @default.
- W2118521160 cites W2011812102 @default.
- W2118521160 cites W2013336473 @default.
- W2118521160 cites W2016200089 @default.
- W2118521160 cites W2019284559 @default.
- W2118521160 cites W2023812395 @default.
- W2118521160 cites W2023994933 @default.
- W2118521160 cites W2024880767 @default.
- W2118521160 cites W2027220714 @default.
- W2118521160 cites W2027813810 @default.
- W2118521160 cites W2028679671 @default.
- W2118521160 cites W2029015825 @default.
- W2118521160 cites W2035421865 @default.
- W2118521160 cites W2036499082 @default.
- W2118521160 cites W2037043502 @default.
- W2118521160 cites W2039539900 @default.
- W2118521160 cites W2042045791 @default.
- W2118521160 cites W2047315382 @default.
- W2118521160 cites W2047894110 @default.
- W2118521160 cites W2051423370 @default.
- W2118521160 cites W2052714177 @default.
- W2118521160 cites W2053850015 @default.
- W2118521160 cites W2054648475 @default.
- W2118521160 cites W2054959632 @default.
- W2118521160 cites W2056245842 @default.
- W2118521160 cites W2060926272 @default.
- W2118521160 cites W2062910236 @default.
- W2118521160 cites W2064385228 @default.
- W2118521160 cites W2065932362 @default.
- W2118521160 cites W2072219714 @default.
- W2118521160 cites W2076766472 @default.
- W2118521160 cites W2078932584 @default.
- W2118521160 cites W2080876332 @default.
- W2118521160 cites W2082407289 @default.
- W2118521160 cites W2085066803 @default.
- W2118521160 cites W2089202379 @default.
- W2118521160 cites W2091187766 @default.
- W2118521160 cites W2091407410 @default.
- W2118521160 cites W2091972041 @default.
- W2118521160 cites W2097570058 @default.
- W2118521160 cites W2098146251 @default.
- W2118521160 cites W2099029901 @default.
- W2118521160 cites W2100973921 @default.
- W2118521160 cites W2100991928 @default.
- W2118521160 cites W2103791867 @default.
- W2118521160 cites W2103934527 @default.
- W2118521160 cites W2104261628 @default.
- W2118521160 cites W2106623141 @default.
- W2118521160 cites W2108025392 @default.
- W2118521160 cites W2110696099 @default.
- W2118521160 cites W2122384242 @default.
- W2118521160 cites W2128966898 @default.
- W2118521160 cites W2129579709 @default.
- W2118521160 cites W2130685024 @default.
- W2118521160 cites W2134083528 @default.
- W2118521160 cites W2134927362 @default.
- W2118521160 cites W2140178312 @default.
- W2118521160 cites W2140658948 @default.
- W2118521160 cites W2147735030 @default.
- W2118521160 cites W2149402043 @default.
- W2118521160 cites W2153038360 @default.
- W2118521160 cites W2153403353 @default.
- W2118521160 cites W2156112600 @default.
- W2118521160 cites W2157504436 @default.
- W2118521160 cites W2163072248 @default.
- W2118521160 cites W2165948024 @default.
- W2118521160 cites W2170298556 @default.
- W2118521160 cites W2220387563 @default.
- W2118521160 cites W2326556724 @default.