FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2118569857> ?p ?o ?g. }

• W2118569857 endingPage "707" @default.
• W2118569857 startingPage "699" @default.
• W2118569857 abstract "Enantiomerically pure drugs and genotyping are promising approaches to achieve optimization in antidepressant therapy. Mirtazapine is a mixed noradrenergic serotoninergic antidepressant used as a racemate. We analyzed pharmacokinetics of its enantiomers in relation to CYP2D6 genotype and in relation to its adverse effects. Mirtazapine was enantioselectively absorbed from the gut with a rate constant of 0.2 min−1 for S(+), but 0.08 min−1 for R(−) mirtazapine. Kinetics of R(−) mirtazapine was only marginally dependent on CYP2D6 genotype, but total clearance of the S(+) enantiomer were 1.3, 2.3, and 3.4 L min−1 in poor, extensive, and ultrarapid metabolizers of CYP2D6 substrates with apparent substantial first-pass metabolism in rapid and ultrarapid metabolizers. Mirtazapine effects on heart rate and blood pressure correlated much more strongly with R(−) then with S(+) concentrations, whereas sedation correlated similarly with both enantiomers. At least concerning some adverse effects, it might be worthwhile to study further mirtazapine enantiospecifically. Clinical Pharmacology & Therapeutics (2007) 81, 699–707. doi:10.1038/sj.clpt.6100116; published online 28 February 2007." @default.
• W2118569857 created "2016-06-24" @default.
• W2118569857 creator A5045212079 @default.
• W2118569857 creator A5064971840 @default.
• W2118569857 creator A5067464550 @default.
• W2118569857 date "2007-02-28" @default.
• W2118569857 modified "2023-09-24" @default.
• W2118569857 title "Pharmacokinetics of Mirtazapine: Enantioselective Effects of the CYP2D6 Ultra Rapid Metabolizer Genotype and Correlation with Adverse Effects" @default.
• W2118569857 cites W1983082039 @default.
• W2118569857 cites W1990522731 @default.
• W2118569857 cites W2001196103 @default.
• W2118569857 cites W2003911804 @default.
• W2118569857 cites W2004557299 @default.
• W2118569857 cites W2009086047 @default.
• W2118569857 cites W2016029871 @default.
• W2118569857 cites W2021593491 @default.
• W2118569857 cites W2024309774 @default.
• W2118569857 cites W2024861187 @default.
• W2118569857 cites W2029951339 @default.
• W2118569857 cites W2032554150 @default.
• W2118569857 cites W2046558323 @default.
• W2118569857 cites W2053783728 @default.
• W2118569857 cites W2071567237 @default.
• W2118569857 cites W2072816949 @default.
• W2118569857 cites W2073991894 @default.
• W2118569857 cites W2079138510 @default.
• W2118569857 cites W2089805423 @default.
• W2118569857 cites W2107202738 @default.
• W2118569857 cites W2132577167 @default.
• W2118569857 cites W2136825478 @default.
• W2118569857 cites W2148803715 @default.
• W2118569857 cites W2270838586 @default.
• W2118569857 cites W4239881928 @default.
• W2118569857 doi "https://doi.org/10.1038/sj.clpt.6100116" @default.
• W2118569857 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/17329996" @default.
• W2118569857 hasPublicationYear "2007" @default.
• W2118569857 type Work @default.
• W2118569857 sameAs 2118569857 @default.
• W2118569857 citedByCount "39" @default.
• W2118569857 countsByYear W21185698572012 @default.
• W2118569857 countsByYear W21185698572013 @default.
• W2118569857 countsByYear W21185698572014 @default.
• W2118569857 countsByYear W21185698572015 @default.
• W2118569857 countsByYear W21185698572016 @default.
• W2118569857 countsByYear W21185698572017 @default.
• W2118569857 countsByYear W21185698572018 @default.
• W2118569857 countsByYear W21185698572019 @default.
• W2118569857 countsByYear W21185698572020 @default.
• W2118569857 countsByYear W21185698572021 @default.
• W2118569857 countsByYear W21185698572022 @default.
• W2118569857 crossrefType "journal-article" @default.
• W2118569857 hasAuthorship W2118569857A5045212079 @default.
• W2118569857 hasAuthorship W2118569857A5064971840 @default.
• W2118569857 hasAuthorship W2118569857A5067464550 @default.
• W2118569857 hasConcept C104317684 @default.
• W2118569857 hasConcept C111113717 @default.
• W2118569857 hasConcept C112705442 @default.
• W2118569857 hasConcept C126322002 @default.
• W2118569857 hasConcept C135763542 @default.
• W2118569857 hasConcept C185592680 @default.
• W2118569857 hasConcept C197934379 @default.
• W2118569857 hasConcept C2776814716 @default.
• W2118569857 hasConcept C2779177272 @default.
• W2118569857 hasConcept C2780831388 @default.
• W2118569857 hasConcept C2781068410 @default.
• W2118569857 hasConcept C2781161787 @default.
• W2118569857 hasConcept C33664856 @default.
• W2118569857 hasConcept C55493867 @default.
• W2118569857 hasConcept C55775858 @default.
• W2118569857 hasConcept C63433958 @default.
• W2118569857 hasConcept C71924100 @default.
• W2118569857 hasConcept C98274493 @default.
• W2118569857 hasConceptScore W2118569857C104317684 @default.
• W2118569857 hasConceptScore W2118569857C111113717 @default.
• W2118569857 hasConceptScore W2118569857C112705442 @default.
• W2118569857 hasConceptScore W2118569857C126322002 @default.
• W2118569857 hasConceptScore W2118569857C135763542 @default.
• W2118569857 hasConceptScore W2118569857C185592680 @default.
• W2118569857 hasConceptScore W2118569857C197934379 @default.
• W2118569857 hasConceptScore W2118569857C2776814716 @default.
• W2118569857 hasConceptScore W2118569857C2779177272 @default.
• W2118569857 hasConceptScore W2118569857C2780831388 @default.
• W2118569857 hasConceptScore W2118569857C2781068410 @default.
• W2118569857 hasConceptScore W2118569857C2781161787 @default.
• W2118569857 hasConceptScore W2118569857C33664856 @default.
• W2118569857 hasConceptScore W2118569857C55493867 @default.
• W2118569857 hasConceptScore W2118569857C55775858 @default.
• W2118569857 hasConceptScore W2118569857C63433958 @default.
• W2118569857 hasConceptScore W2118569857C71924100 @default.
• W2118569857 hasConceptScore W2118569857C98274493 @default.
• W2118569857 hasIssue "5" @default.
• W2118569857 hasLocation W21185698571 @default.
• W2118569857 hasLocation W21185698572 @default.
• W2118569857 hasOpenAccess W2118569857 @default.
• W2118569857 hasPrimaryLocation W21185698571 @default.
• W2118569857 hasRelatedWork W1991575059 @default.
• W2118569857 hasRelatedWork W2003812680 @default.
• W2118569857 hasRelatedWork W2016029871 @default.

• next