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• W2118575265 abstract "Summary Extracellular signaling during inflammation and chronic diseases involves molecules referred to as ‘ D anger S ignals’ ( DS ), including the small molecule adenosine. We demonstrate that primary gingival epithelial cells ( GEC ) express a family of G ‐protein coupled receptors known as adenosine receptors, including the high‐affinity receptors A 1 and A 2a and low‐affinity receptors A 2b and A 3. Treatment of Porphyromonas gingivalis ‐infected GEC with the A 2a receptor‐specific agonist CGS ‐21680 resulted in elevated intracellular bacterial replication as determined by fluorescence microscopy and antibiotic protection assay. Additionally, A 2a receptor antagonism and knockdown via RNA interference significantly reduced metabolically active intracellular P. gingivalis . Furthermore, analysis of anti‐inflammatory mediator cyclic AMP (c AMP ) following A 2a receptor selective agonist CGS ‐21680 stimulation induced significantly higher levels of c AMP during P. gingivalis infection, indicating that adenosine signaling may attenuate inflammatory processes associated with bacterial infection. This study reveals that the GEC express functional A 2a receptor and P. gingivalis may use the A 2a receptor coupled DS adenosine signaling as a means to establish successful persistence in the oral mucosa, possibly via downregulation of the pro‐inflammatory response." @default.
• W2118575265 created "2016-06-24" @default.
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• W2118575265 date "2014-02-12" @default.
• W2118575265 modified "2023-10-03" @default.
• W2118575265 title "Danger signal adenosine via adenosine 2a receptor stimulates growth of<i>Porphyromonas gingivalis</i>in primary gingival epithelial cells" @default.
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• W2118575265 doi "https://doi.org/10.1111/omi.12045" @default.
• W2118575265 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3960722" @default.
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