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- W2118577530 abstract "We compared the analytical performance of the CE instrument Paragon CZE (Beckman) and the new instrument Capillarys recently developed by Sebia. Within- and between-day imprecision, variability among capillaries, interference from hemoglobin and fibrinogen, linearity, and sensitivity for monoclonal components (MC) detection have been estimated. For comparison studies, 313 unselected sera were simultaneously processed with both instruments. Within-day CV's were 1.07% and 0.62% for albumin, 3.98% and 3.90% for α1, 2.41% and 4.17% for α2-, 1.58% and 3.69% for β-, and 1.20% and 1.78% for γ- globulins; betweenday CV's were 0.90% and 0.78% for albumin, 6.43% and 3.80% for α1, 5.70% and 4.53% for α2-, 3.72% and 2.66% for β-, and 2.19% and 2.32% for γ- globulins for Capillarys and Paragon CZE, respectively. Bland-Altman (n=273) analysis showed low mean differences between the electrophoretic fractions measured by the 2 instruments, but all the fractions demonstrated a systematic difference, possibly due to a difference in electrophoretic mobility. The 2 systems showed a substantially superimposable ability in revealing MCs (n=175). The detection limit of MCs was 0.4 g/L for both systems. The analytical performance of the new instrument Capillarys is substantially comparable to that of Paragon CZE." @default.
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- W2118577530 date "2006-04-01" @default.
- W2118577530 modified "2023-10-04" @default.
- W2118577530 title "Serum Proteins Capillary Zone Electrophoresis: A Comparison of Two Systems" @default.
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- W2118577530 doi "https://doi.org/10.1309/e8p5gxdwakdp3b0q" @default.
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