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- W2118590728 abstract "Significance Neurons communicate at synapses through neurotransmitters. For sustained neuronal signaling, neurotransmitters are recycled after release from neuronal terminals. During this process, perisynaptic glial cells take in and convert neurotransmitters such as glutamate, GABA, and histamine into inactive metabolites for transport. It has been assumed that inactive metabolites are delivered directly into neighboring neuronal terminals for neurotransmitter regeneration. Our work in the fruit fly, however, demonstrates that a gap junction-dependent multicellular glial network transports metabolites of histamine between perisynaptic glia and cell bodies of photoreceptor neurons, and this is required for visual signal transmission and alert behavior. Thus, by mediating this novel, long-distance recycling of neurotransmitters, intercellular glial networks play an important role in the maintenance of neuronal functions." @default.
- W2118590728 created "2016-06-24" @default.
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- W2118590728 creator A5065073978 @default.
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- W2118590728 date "2014-02-03" @default.
- W2118590728 modified "2023-10-17" @default.
- W2118590728 title "Long-distance mechanism of neurotransmitter recycling mediated by glial network facilitates visual function in <i>Drosophila</i>" @default.
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- W2118590728 doi "https://doi.org/10.1073/pnas.1323714111" @default.
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