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- W2118595673 abstract "<h3>Objective:</h3> To monitor the systemic immune responses of patients with multiple sclerosis (MS) under treatment with GNbAC1, a monoclonal antibody against the envelope protein of the MS- associated retrovirus, during a phase 2a trial. <h3>Methods:</h3> We analyzed the composition of immune cell subsets and the activation level of monocytes by flow cytometry and the response against viral and vaccine antigens by ELISpot. <h3>Results:</h3> None of the endpoints measured revealed any immunosuppressive effect of the therapeutic antibody. Activation of monocytes slightly decreased during treatment as predicted by the hypothesized mechanism of action of GNbAC1. <h3>Conclusion:</h3> These results support the conclusion that the antibody is safe for use in patients with MS. <h3>Classification of evidence:</h3> This study provides Class III evidence that in patients with MS GNbAC1 does not significantly affect several biomarkers of systemic immune response." @default.
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- W2118595673 date "2015-08-20" @default.
- W2118595673 modified "2023-10-16" @default.
- W2118595673 title "Immunologic monitoring during a phase 2a trial of the GNbAC1 antibody in patients with MS" @default.
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- W2118595673 doi "https://doi.org/10.1212/nxi.0000000000000144" @default.
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