Matches in SemOpenAlex for { <https://semopenalex.org/work/W2118598881> ?p ?o ?g. }
- W2118598881 endingPage "1132" @default.
- W2118598881 startingPage "1124" @default.
- W2118598881 abstract "Cancer cachexia is a multi-factorial syndrome that encompasses a spectrum from early weight loss (pre-cachexia) to a state of severe incapacity incompatible with life. The molecular basis of the syndrome in animal models (based on host–tumour cell interaction, the neuro-hormonal control of appetite and the hypertrophy/atrophy pathways that govern muscle-wasting) has provided a new raft of biomarkers and therapeutic targets. Key defining features of cachexia in humans (weight loss, reduced food intake and systemic inflammation) now provide not only a framework for classification but also a rationale for targets for therapeutic intervention. The role of age and immobility in muscle-wasting also provides a rationale for the nature of nutritional support in cachexia. There is now a substantive evidence that multimodal approaches that address these key issues can stabilise and even improve the nutritional status, function and quality of life of at least a proportion of advanced cancer patients. Novel biomarkers for patient stratification and more specific techniques for the estimation of muscle mass and physical activity level herald a new era in trial design. The current evidence-base justifies new enthusiasm for the design of complex intervention studies in the management of cancer cachexia." @default.
- W2118598881 created "2016-06-24" @default.
- W2118598881 creator A5017006323 @default.
- W2118598881 date "2008-05-01" @default.
- W2118598881 modified "2023-10-18" @default.
- W2118598881 title "Cancer cachexia: Developing multimodal therapy for a multidimensional problem" @default.
- W2118598881 cites W1493883088 @default.
- W2118598881 cites W1601347251 @default.
- W2118598881 cites W1794985913 @default.
- W2118598881 cites W1880398352 @default.
- W2118598881 cites W1896432851 @default.
- W2118598881 cites W1935009453 @default.
- W2118598881 cites W1964440334 @default.
- W2118598881 cites W1967645160 @default.
- W2118598881 cites W1979243593 @default.
- W2118598881 cites W1979855377 @default.
- W2118598881 cites W1981187546 @default.
- W2118598881 cites W1989462593 @default.
- W2118598881 cites W1994249441 @default.
- W2118598881 cites W1994903286 @default.
- W2118598881 cites W1995287920 @default.
- W2118598881 cites W1996195782 @default.
- W2118598881 cites W2002712062 @default.
- W2118598881 cites W2004253639 @default.
- W2118598881 cites W2014899456 @default.
- W2118598881 cites W2022990280 @default.
- W2118598881 cites W2024946243 @default.
- W2118598881 cites W2027279302 @default.
- W2118598881 cites W2031238420 @default.
- W2118598881 cites W2034924160 @default.
- W2118598881 cites W2046387692 @default.
- W2118598881 cites W2046933339 @default.
- W2118598881 cites W2057482464 @default.
- W2118598881 cites W2058570498 @default.
- W2118598881 cites W2059967711 @default.
- W2118598881 cites W2061114783 @default.
- W2118598881 cites W2067623537 @default.
- W2118598881 cites W2068008235 @default.
- W2118598881 cites W2068359467 @default.
- W2118598881 cites W2074468582 @default.
- W2118598881 cites W2078608486 @default.
- W2118598881 cites W2093245662 @default.
- W2118598881 cites W2094990798 @default.
- W2118598881 cites W2102283666 @default.
- W2118598881 cites W2102589258 @default.
- W2118598881 cites W2109956558 @default.
- W2118598881 cites W2119303027 @default.
- W2118598881 cites W2119448420 @default.
- W2118598881 cites W2127206464 @default.
- W2118598881 cites W2127471618 @default.
- W2118598881 cites W2129889907 @default.
- W2118598881 cites W2131979270 @default.
- W2118598881 cites W2137687978 @default.
- W2118598881 cites W2152788537 @default.
- W2118598881 cites W2153387767 @default.
- W2118598881 cites W2154490896 @default.
- W2118598881 cites W2161943291 @default.
- W2118598881 cites W2162254318 @default.
- W2118598881 cites W2164948224 @default.
- W2118598881 cites W2165868509 @default.
- W2118598881 cites W2167620866 @default.
- W2118598881 cites W2231531642 @default.
- W2118598881 cites W2335452552 @default.
- W2118598881 cites W34091820 @default.
- W2118598881 cites W4245923436 @default.
- W2118598881 cites W71156707 @default.
- W2118598881 doi "https://doi.org/10.1016/j.ejca.2008.02.033" @default.
- W2118598881 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/18375115" @default.
- W2118598881 hasPublicationYear "2008" @default.
- W2118598881 type Work @default.
- W2118598881 sameAs 2118598881 @default.
- W2118598881 citedByCount "369" @default.
- W2118598881 countsByYear W21185988812012 @default.
- W2118598881 countsByYear W21185988812013 @default.
- W2118598881 countsByYear W21185988812014 @default.
- W2118598881 countsByYear W21185988812015 @default.
- W2118598881 countsByYear W21185988812016 @default.
- W2118598881 countsByYear W21185988812017 @default.
- W2118598881 countsByYear W21185988812018 @default.
- W2118598881 countsByYear W21185988812019 @default.
- W2118598881 countsByYear W21185988812020 @default.
- W2118598881 countsByYear W21185988812021 @default.
- W2118598881 countsByYear W21185988812022 @default.
- W2118598881 countsByYear W21185988812023 @default.
- W2118598881 crossrefType "journal-article" @default.
- W2118598881 hasAuthorship W2118598881A5017006323 @default.
- W2118598881 hasConcept C121608353 @default.
- W2118598881 hasConcept C126322002 @default.
- W2118598881 hasConcept C159110408 @default.
- W2118598881 hasConcept C177713679 @default.
- W2118598881 hasConcept C2776252253 @default.
- W2118598881 hasConcept C2776263037 @default.
- W2118598881 hasConcept C2776914184 @default.
- W2118598881 hasConcept C2777704314 @default.
- W2118598881 hasConcept C2779764123 @default.
- W2118598881 hasConcept C2779951463 @default.
- W2118598881 hasConcept C2781172350 @default.
- W2118598881 hasConcept C2911126609 @default.