FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2118610591> ?p ?o ?g. }

• W2118610591 abstract "A markedly decreased aortic nitric oxide (NO) availability, probably due to impaired endothelial nitric oxide synthase activity with enhanced O2- and peroxynitrite production, seems to be attributable to endothelial dysfunction in spontaneously hypertensive rats (SHR) with severe congestive heart failure (CHF). In this study, we investigated the chronic effect of the angiotensin-converting enzyme inhibitor, ramipril (RA) and the loop diuretic, frusemide (FU), as well as the combination of both on endothelial NO, O2- and peroxynitrite production in aortae from SHR with failing hearts after myocardial infarction (MI). Heart failure was induced by permanent occlusion of the left coronary artery. SHR were randomised to receive either placebo, RA, (1 mg/kg/day), FU (4 mg/kg/day) or RA+FU (1 and 4 mg/kg/day, respectively). Treatments were started two weeks following MI and continued for six weeks. Reduced aortic and coronary flow indices in the working heart, which can be considered as markers for endothelial function, were significantly normalised and improved, respectively, by RA, FU or RA+FU-treatment. Similarly, all three treatment regimens significantly enhanced the reduced calcium ionophore (CaI)-induced NO-release (assessed by a NO-sensitive microsensor) from aortic endothelial cells of placebo-treated animals with CHF. Concomitantly, the increased CaI-stimulated O2- production (assessed by an electrochemical sensor) in aortic endothelial cells of placebo-treated animals with CHF was significantly reduced by RA and RA+FU-treatment. Treatment with RA and RA+FU also attenuated the dramatic increase in endothelial peroxynitrite concentration (chemiluminescence method), which was observed in placebo-treated rats with CHF. FU did not counteract improved haemo- and cardiodynamic parameters by RA. Thus, RA and FU act synergistically to enhance bioavailability of endothelium-derived NO, and this may contribute to the clinical usefulness of the combination of these drugs in treatment of heart failure." @default.
• W2118610591 created "2016-06-24" @default.
• W2118610591 creator A5004490629 @default.
• W2118610591 creator A5013029659 @default.
• W2118610591 creator A5046255700 @default.
• W2118610591 creator A5054190898 @default.
• W2118610591 creator A5065155891 @default.
• W2118610591 date "2003-09-01" @default.
• W2118610591 modified "2023-10-16" @default.
• W2118610591 title "Ramipril improves nitric oxide availability in hypertensive rats with failing hearts after myocardial infarction" @default.
• W2118610591 cites W179756410 @default.
• W2118610591 cites W180946569 @default.
• W2118610591 cites W1967785796 @default.
• W2118610591 cites W1969512514 @default.
• W2118610591 cites W1976555160 @default.
• W2118610591 cites W1977455736 @default.
• W2118610591 cites W1990680377 @default.
• W2118610591 cites W2009359363 @default.
• W2118610591 cites W2014905160 @default.
• W2118610591 cites W2028455468 @default.
• W2118610591 cites W2028655703 @default.
• W2118610591 cites W2032412051 @default.
• W2118610591 cites W2056135909 @default.
• W2118610591 cites W2063775163 @default.
• W2118610591 cites W2071756355 @default.
• W2118610591 cites W2073274738 @default.
• W2118610591 cites W2073740998 @default.
• W2118610591 cites W2080123530 @default.
• W2118610591 cites W2085036059 @default.
• W2118610591 cites W2087747156 @default.
• W2118610591 cites W2088285166 @default.
• W2118610591 cites W2089258822 @default.
• W2118610591 cites W2093369326 @default.
• W2118610591 cites W2110182057 @default.
• W2118610591 cites W2135122986 @default.
• W2118610591 cites W2136423707 @default.
• W2118610591 cites W2142242002 @default.
• W2118610591 cites W2144391460 @default.
• W2118610591 cites W2155043219 @default.
• W2118610591 cites W2158990159 @default.
• W2118610591 cites W2183605994 @default.
• W2118610591 cites W2243837337 @default.
• W2118610591 cites W2441878559 @default.
• W2118610591 cites W2585382523 @default.
• W2118610591 doi "https://doi.org/10.3317/jraas.2003.029" @default.
• W2118610591 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/14608524" @default.
• W2118610591 hasPublicationYear "2003" @default.
• W2118610591 type Work @default.
• W2118610591 sameAs 2118610591 @default.
• W2118610591 citedByCount "10" @default.
• W2118610591 countsByYear W21186105912013 @default.
• W2118610591 countsByYear W21186105912016 @default.
• W2118610591 crossrefType "journal-article" @default.
• W2118610591 hasAuthorship W2118610591A5004490629 @default.
• W2118610591 hasAuthorship W2118610591A5013029659 @default.
• W2118610591 hasAuthorship W2118610591A5046255700 @default.
• W2118610591 hasAuthorship W2118610591A5054190898 @default.
• W2118610591 hasAuthorship W2118610591A5065155891 @default.
• W2118610591 hasBestOaLocation W21186105911 @default.
• W2118610591 hasConcept C126322002 @default.
• W2118610591 hasConcept C134018914 @default.
• W2118610591 hasConcept C164705383 @default.
• W2118610591 hasConcept C181199279 @default.
• W2118610591 hasConcept C185592680 @default.
• W2118610591 hasConcept C27016395 @default.
• W2118610591 hasConcept C2776992346 @default.
• W2118610591 hasConcept C2777622882 @default.
• W2118610591 hasConcept C2778198053 @default.
• W2118610591 hasConcept C2778326061 @default.
• W2118610591 hasConcept C2778784160 @default.
• W2118610591 hasConcept C2779611605 @default.
• W2118610591 hasConcept C2779888176 @default.
• W2118610591 hasConcept C2780795997 @default.
• W2118610591 hasConcept C2780972559 @default.
• W2118610591 hasConcept C500558357 @default.
• W2118610591 hasConcept C519581460 @default.
• W2118610591 hasConcept C55493867 @default.
• W2118610591 hasConcept C71924100 @default.
• W2118610591 hasConcept C84393581 @default.
• W2118610591 hasConceptScore W2118610591C126322002 @default.
• W2118610591 hasConceptScore W2118610591C134018914 @default.
• W2118610591 hasConceptScore W2118610591C164705383 @default.
• W2118610591 hasConceptScore W2118610591C181199279 @default.
• W2118610591 hasConceptScore W2118610591C185592680 @default.
• W2118610591 hasConceptScore W2118610591C27016395 @default.
• W2118610591 hasConceptScore W2118610591C2776992346 @default.
• W2118610591 hasConceptScore W2118610591C2777622882 @default.
• W2118610591 hasConceptScore W2118610591C2778198053 @default.
• W2118610591 hasConceptScore W2118610591C2778326061 @default.
• W2118610591 hasConceptScore W2118610591C2778784160 @default.
• W2118610591 hasConceptScore W2118610591C2779611605 @default.
• W2118610591 hasConceptScore W2118610591C2779888176 @default.
• W2118610591 hasConceptScore W2118610591C2780795997 @default.
• W2118610591 hasConceptScore W2118610591C2780972559 @default.
• W2118610591 hasConceptScore W2118610591C500558357 @default.
• W2118610591 hasConceptScore W2118610591C519581460 @default.
• W2118610591 hasConceptScore W2118610591C55493867 @default.
• W2118610591 hasConceptScore W2118610591C71924100 @default.
• W2118610591 hasConceptScore W2118610591C84393581 @default.
• W2118610591 hasLocation W21186105911 @default.

• next