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- W2118611271 endingPage "945" @default.
- W2118611271 startingPage "935" @default.
- W2118611271 abstract "There is an urgent need for effective pharmacological therapies to help tackle the growing obesity epidemic and the healthcare crisis it poses. The past 3 years have seen approval of a number of novel anti-obesity drugs. The majority of these influence hypothalamic appetite pathways via dopaminergic or serotoninergic signalling. Some are combination therapies, allowing lower doses to minimize the potential for off-target effects. An alternative approach is to mimic endogenous satiety signals using long-lasting forms of peripheral appetite-suppressing hormones. There is also considerable interest in targeting thermogenesis by brown adipose tissue to increase resting energy expenditure. Obesity pharmacotherapy has seen several false dawns, but improved understanding of the pathways regulating energy balance, and better-designed trials, give many greater confidence that recently approved agents will be both efficacious and safe. Nevertheless, a number of issues from preclinical and clinical development continue to attract debate, and additional large-scale trials are still required to address areas of uncertainty." @default.
- W2118611271 created "2016-06-24" @default.
- W2118611271 creator A5011196462 @default.
- W2118611271 creator A5055696357 @default.
- W2118611271 date "2015-05-19" @default.
- W2118611271 modified "2023-10-18" @default.
- W2118611271 title "The New Era of Drug Therapy for Obesity: The Evidence and the Expectations" @default.
- W2118611271 cites W109691321 @default.
- W2118611271 cites W1953708939 @default.
- W2118611271 cites W1959935877 @default.
- W2118611271 cites W1965079305 @default.
- W2118611271 cites W1966193292 @default.
- W2118611271 cites W1969385890 @default.
- W2118611271 cites W1974839423 @default.
- W2118611271 cites W1978454776 @default.
- W2118611271 cites W1982350907 @default.
- W2118611271 cites W1982526347 @default.
- W2118611271 cites W1982891950 @default.
- W2118611271 cites W1988807128 @default.
- W2118611271 cites W1989431420 @default.
- W2118611271 cites W1991778481 @default.
- W2118611271 cites W1993582432 @default.
- W2118611271 cites W1997115741 @default.
- W2118611271 cites W2000026186 @default.
- W2118611271 cites W2001562531 @default.
- W2118611271 cites W2001588817 @default.
- W2118611271 cites W2002941555 @default.
- W2118611271 cites W2005136472 @default.
- W2118611271 cites W2014735081 @default.
- W2118611271 cites W2015788437 @default.
- W2118611271 cites W2015936758 @default.
- W2118611271 cites W2020982355 @default.
- W2118611271 cites W2024440860 @default.
- W2118611271 cites W2026149528 @default.
- W2118611271 cites W2028502361 @default.
- W2118611271 cites W2033285271 @default.
- W2118611271 cites W2040328785 @default.
- W2118611271 cites W2040494553 @default.
- W2118611271 cites W2045387309 @default.
- W2118611271 cites W2045637690 @default.
- W2118611271 cites W2046809238 @default.
- W2118611271 cites W2050439317 @default.
- W2118611271 cites W2054895323 @default.
- W2118611271 cites W2057913111 @default.
- W2118611271 cites W2058032165 @default.
- W2118611271 cites W2058922633 @default.
- W2118611271 cites W2068618758 @default.
- W2118611271 cites W2071835038 @default.
- W2118611271 cites W2078060668 @default.
- W2118611271 cites W2078611185 @default.
- W2118611271 cites W2081767732 @default.
- W2118611271 cites W2082206299 @default.
- W2118611271 cites W2091685843 @default.
- W2118611271 cites W2092434810 @default.
- W2118611271 cites W2096048424 @default.
- W2118611271 cites W2102264538 @default.
- W2118611271 cites W2108365604 @default.
- W2118611271 cites W2108606500 @default.
- W2118611271 cites W2109366467 @default.
- W2118611271 cites W2109487793 @default.
- W2118611271 cites W2109662292 @default.
- W2118611271 cites W2109941637 @default.
- W2118611271 cites W2110438413 @default.
- W2118611271 cites W2110893190 @default.
- W2118611271 cites W2112222692 @default.
- W2118611271 cites W2112714350 @default.
- W2118611271 cites W2113572448 @default.
- W2118611271 cites W2113941930 @default.
- W2118611271 cites W2116949156 @default.
- W2118611271 cites W2117449343 @default.
- W2118611271 cites W2119446720 @default.
- W2118611271 cites W2119779723 @default.
- W2118611271 cites W2123931921 @default.
- W2118611271 cites W2125239733 @default.
- W2118611271 cites W2128933506 @default.
- W2118611271 cites W2128939426 @default.
- W2118611271 cites W2130210878 @default.
- W2118611271 cites W2132144189 @default.
- W2118611271 cites W2132897587 @default.
- W2118611271 cites W2134362869 @default.
- W2118611271 cites W2137265173 @default.
- W2118611271 cites W2137700844 @default.
- W2118611271 cites W2137765752 @default.
- W2118611271 cites W2144589456 @default.
- W2118611271 cites W2146484653 @default.
- W2118611271 cites W2148287957 @default.
- W2118611271 cites W2148449799 @default.
- W2118611271 cites W2149225145 @default.
- W2118611271 cites W2152423343 @default.
- W2118611271 cites W2154842844 @default.
- W2118611271 cites W2157135485 @default.
- W2118611271 cites W2157324975 @default.
- W2118611271 cites W2158351892 @default.
- W2118611271 cites W2158822657 @default.
- W2118611271 cites W2161325242 @default.
- W2118611271 cites W2164410780 @default.
- W2118611271 cites W2184401029 @default.
- W2118611271 cites W2321245768 @default.