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- W2118612419 abstract "Huntington's disease is a dominant autosomal neurodegenerative disorder caused by an expansion of polyglutamines in the huntingtin (Htt) protein, whose cellular function remains controversial. To gain insight into Htt function, we purified epitope-tagged Htt and identified Argonaute as associated proteins. Colocalization studies demonstrated Htt and Ago2 to be present in P bodies, and depletion of Htt showed compromised RNA-mediated gene silencing. Mouse striatal cells expressing mutant Htt showed fewer P bodies and reduced reporter gene silencing activity compared with wild-type counterparts. These data suggest that the previously reported transcriptional deregulation in HD may be attributed in part to mutant Htt's role in post-transcriptional processes." @default.
- W2118612419 created "2016-06-24" @default.
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- W2118612419 date "2008-08-05" @default.
- W2118612419 modified "2023-10-07" @default.
- W2118612419 title "Huntington's disease protein contributes to RNA-mediated gene silencing through association with Argonaute and P bodies" @default.
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- W2118612419 doi "https://doi.org/10.1073/pnas.0800658105" @default.
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