FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2118640511> ?p ?o ?g. }

• W2118640511 endingPage "32" @default.
• W2118640511 startingPage "25" @default.
• W2118640511 abstract "OBJECTIVE--To assess the likely importance of matrix metalloproteinases (MMPs) and their inhibitors (TIMPs) in the arthritic process. METHODS--Synovial samples from seven joints with rheumatoid arthritis and three osteoarthritic joints were analysed by indirect immunofluorescence microscopy. Using specific human antisera, we documented the frequencies and distributions of collagenase, stromelysins 1 and 2, matrilysin, gelatinases A and B, TIMP-1, and TIMP-2. RESULTS--Stromelysin 1 was found in all synovia, bound to extracellular matrix, within cells, or both, indicating stromelysin synthesis. Matrilysin was present in only one active inflammatory synovium, and focal synthesis of collagenase and gelatinase A was seen in four synovia. Stromelysin 2 and TIMP-2 were not observed, but TIMP-1 synthesis was seen in five synovia, and in two active synovia the distribution of TIMP-1 positive cells was more widespread than that of MMPs. CONCLUSIONS--The presence of stromelysin 1 in all synovia clearly implicates this enzyme in joint damage. Collagenase, gelatinase A and matrilysin may also have a role in rheumatoid arthritis, but are not significant in osteoarthritis. However, marked regional variations were found in the synthesis of these MMPs, indicating not only that these diseases are episodic but that control of enzyme synthesis is focal. Only TIMP-1 may be considered an inhibitory factor." @default.
• W2118640511 created "2016-06-24" @default.
• W2118640511 creator A5048755383 @default.
• W2118640511 creator A5054795648 @default.
• W2118640511 creator A5059458143 @default.
• W2118640511 creator A5075311619 @default.
• W2118640511 date "1995-01-01" @default.
• W2118640511 modified "2023-09-27" @default.
• W2118640511 title "Immunolocalisation studies on six matrix metalloproteinases and their inhibitors, TIMP-1 and TIMP-2, in synovia from patients with osteo- and rheumatoid arthritis." @default.
• W2118640511 cites W1251255684 @default.
• W2118640511 cites W1560533935 @default.
• W2118640511 cites W1567385135 @default.
• W2118640511 cites W1599093134 @default.
• W2118640511 cites W1628604166 @default.
• W2118640511 cites W1700189391 @default.
• W2118640511 cites W1963594744 @default.
• W2118640511 cites W1965729227 @default.
• W2118640511 cites W1972153522 @default.
• W2118640511 cites W1972861978 @default.
• W2118640511 cites W1982172588 @default.
• W2118640511 cites W1995304518 @default.
• W2118640511 cites W2000532033 @default.
• W2118640511 cites W2003152672 @default.
• W2118640511 cites W2006319254 @default.
• W2118640511 cites W2022205459 @default.
• W2118640511 cites W2030256425 @default.
• W2118640511 cites W2040066204 @default.
• W2118640511 cites W2045946354 @default.
• W2118640511 cites W2052396295 @default.
• W2118640511 cites W2068406471 @default.
• W2118640511 cites W2077679509 @default.
• W2118640511 cites W2095165075 @default.
• W2118640511 cites W2102397013 @default.
• W2118640511 cites W2133692536 @default.
• W2118640511 cites W2142293801 @default.
• W2118640511 cites W2254579098 @default.
• W2118640511 cites W2266035872 @default.
• W2118640511 cites W2300250634 @default.
• W2118640511 cites W2312266309 @default.
• W2118640511 cites W238232679 @default.
• W2118640511 cites W2394674621 @default.
• W2118640511 cites W2402260991 @default.
• W2118640511 cites W2407546525 @default.
• W2118640511 cites W2424456688 @default.
• W2118640511 doi "https://doi.org/10.1136/ard.54.1.25" @default.
• W2118640511 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/1005508" @default.
• W2118640511 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/7880117" @default.
• W2118640511 hasPublicationYear "1995" @default.
• W2118640511 type Work @default.
• W2118640511 sameAs 2118640511 @default.
• W2118640511 citedByCount "161" @default.
• W2118640511 countsByYear W21186405112012 @default.
• W2118640511 countsByYear W21186405112013 @default.
• W2118640511 countsByYear W21186405112014 @default.
• W2118640511 countsByYear W21186405112015 @default.
• W2118640511 countsByYear W21186405112016 @default.
• W2118640511 countsByYear W21186405112017 @default.
• W2118640511 countsByYear W21186405112018 @default.
• W2118640511 countsByYear W21186405112019 @default.
• W2118640511 countsByYear W21186405112020 @default.
• W2118640511 countsByYear W21186405112021 @default.
• W2118640511 crossrefType "journal-article" @default.
• W2118640511 hasAuthorship W2118640511A5048755383 @default.
• W2118640511 hasAuthorship W2118640511A5054795648 @default.
• W2118640511 hasAuthorship W2118640511A5059458143 @default.
• W2118640511 hasAuthorship W2118640511A5075311619 @default.
• W2118640511 hasBestOaLocation W21186405111 @default.
• W2118640511 hasConcept C109523444 @default.
• W2118640511 hasConcept C126322002 @default.
• W2118640511 hasConcept C142724271 @default.
• W2118640511 hasConcept C181199279 @default.
• W2118640511 hasConcept C189165786 @default.
• W2118640511 hasConcept C203014093 @default.
• W2118640511 hasConcept C204787440 @default.
• W2118640511 hasConcept C2776164576 @default.
• W2118640511 hasConcept C2776223131 @default.
• W2118640511 hasConcept C2776232661 @default.
• W2118640511 hasConcept C2777077863 @default.
• W2118640511 hasConcept C2777575956 @default.
• W2118640511 hasConcept C2777652487 @default.
• W2118640511 hasConcept C2778394429 @default.
• W2118640511 hasConcept C2779939298 @default.
• W2118640511 hasConcept C2910007452 @default.
• W2118640511 hasConcept C2910246616 @default.
• W2118640511 hasConcept C55493867 @default.
• W2118640511 hasConcept C71924100 @default.
• W2118640511 hasConcept C86803240 @default.
• W2118640511 hasConcept C95444343 @default.
• W2118640511 hasConceptScore W2118640511C109523444 @default.
• W2118640511 hasConceptScore W2118640511C126322002 @default.
• W2118640511 hasConceptScore W2118640511C142724271 @default.
• W2118640511 hasConceptScore W2118640511C181199279 @default.
• W2118640511 hasConceptScore W2118640511C189165786 @default.
• W2118640511 hasConceptScore W2118640511C203014093 @default.
• W2118640511 hasConceptScore W2118640511C204787440 @default.
• W2118640511 hasConceptScore W2118640511C2776164576 @default.
• W2118640511 hasConceptScore W2118640511C2776223131 @default.
• W2118640511 hasConceptScore W2118640511C2776232661 @default.

• next