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- W2118641518 abstract "There have been only two reports of acute graft vs host disease (aGVHD) in kidney graft recipients, and these were apparently due to blood transfusions [1,2]. We report the first case of donor-derived aGVHD occurring in a kidney transplant patient who received a graft from a ‘0 HLA mismatched’ donor. aGVHD is more often reported in intestinal or liver transplant recipients. The diagnosis is often delayed because the early signs are attributed to drug reactions or infections. These include skin rash, fever, diarrhoea and/or liver dysfunction. Later the patients develop pancytopenia, pre-disposing them to infection and bleeding, which are the most frequent causes of death [3]. The transplanted organ is noticeably spared since it is of donor origin. Mortality is very high, particularly once the patient becomes pancytopenic. The diagnosis is confirmed by demonstrating large numbers of donor lymphocytes in the patient’s circulation. Close matching of HLA antigens between the donor and the recipient is the strongest risk factor for aGVHD in liver transplant recipients. However, such close HLA matches are very common in kidney transplant recipients because these ‘0 HLA antigen mismatched’ transplants are given high priority. We present this case in order to raise awareness that aGVHD can occur after kidney transplantation. Case report" @default.
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- W2118641518 date "2006-04-20" @default.
- W2118641518 modified "2023-10-01" @default.
- W2118641518 title "Graft vs host disease following kidney transplantation using an ‘0 HLA antigen mismatched’ donor" @default.
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- W2118641518 doi "https://doi.org/10.1093/ndt/gfl174" @default.
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