FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2118656858> ?p ?o ?g. }

• W2118656858 endingPage "494" @default.
• W2118656858 startingPage "487" @default.
• W2118656858 abstract "The association is still not clear between the common APOE polymorphism and coronary heart disease (CHD) risk, nor its modulation by diet. Thus, our aim was to study the association between the APOE genotypes and incident CHD and how dietary fat and alcohol consumption modify these effects. We performed a nested case-control study in the Spanish European Prospective Investigation into Cancer and Nutrition cohort. Healthy men and women (41,440, 30-69 years) were followed up over a 10-year period, with the incident CHD cases being identified. We analyzed 534 incident CHD cases and 1123 controls. APOE, dietary intake and plasma lipids were determined at baseline. The APOE polymorphism was significantly associated with low-density lipoprotein cholesterol (LDL-C), and gene-alcohol interactions in determining LDL-C were detected. In the whole population, the E2 allele was significantly associated with a lower CHD risk than E3/E3 subjects [odds ratio (OR), 0.58; 95% confidence interval (CI), 0.38-0.89]. The E4 allele did not reach statistical significance vs. E3/E3 (OR, 1.17; 95% CI, 0.88-1.58). However, saturated fat intake modified the effect of the APOE polymorphism in determining CHD risk. When saturated fat intake was low (<10% of energy), no statistically significant association between the APOE polymorphism and CHD risk was observed (P=.682). However, with higher intake (≥10%), the polymorphism was significant (P=.005), and the differences between E2 and E4 carriers were magnified (OR for E4 vs. E2, 3.33; 95% CI, 1.61-6.90). Alcohol consumption also modified the effect of the APOE on CHD risk. In conclusion, in this Mediterranean population, the E2 allele is associated with lower CHD risk, and this association is modulated by saturated fat and alcohol consumption." @default.
• W2118656858 created "2016-06-24" @default.
• W2118656858 creator A5010285332 @default.
• W2118656858 creator A5011071446 @default.
• W2118656858 creator A5011645109 @default.
• W2118656858 creator A5021978850 @default.
• W2118656858 creator A5029854453 @default.
• W2118656858 creator A5030130509 @default.
• W2118656858 creator A5036804726 @default.
• W2118656858 creator A5041241937 @default.
• W2118656858 creator A5066215372 @default.
• W2118656858 creator A5066883080 @default.
• W2118656858 creator A5070082049 @default.
• W2118656858 creator A5070104506 @default.
• W2118656858 creator A5074335035 @default.
• W2118656858 creator A5079343036 @default.
• W2118656858 creator A5081155326 @default.
• W2118656858 creator A5083031774 @default.
• W2118656858 creator A5083408230 @default.
• W2118656858 creator A5084605060 @default.
• W2118656858 creator A5091871456 @default.
• W2118656858 date "2011-05-01" @default.
• W2118656858 modified "2023-10-17" @default.
• W2118656858 title "Saturated fat intake and alcohol consumption modulate the association between the APOE polymorphism and risk of future coronary heart disease: a nested case-control study in the Spanish EPIC cohort" @default.
• W2118656858 cites W1267885419 @default.
• W2118656858 cites W1589217226 @default.
• W2118656858 cites W1630952711 @default.
• W2118656858 cites W1970057214 @default.
• W2118656858 cites W1971525576 @default.
• W2118656858 cites W1975396627 @default.
• W2118656858 cites W1986654454 @default.
• W2118656858 cites W1999840769 @default.
• W2118656858 cites W2001052319 @default.
• W2118656858 cites W2001131580 @default.
• W2118656858 cites W2019846803 @default.
• W2118656858 cites W2025184410 @default.
• W2118656858 cites W2031583285 @default.
• W2118656858 cites W2050555193 @default.
• W2118656858 cites W2061571369 @default.
• W2118656858 cites W2063582765 @default.
• W2118656858 cites W2066644955 @default.
• W2118656858 cites W2070451449 @default.
• W2118656858 cites W2070786702 @default.
• W2118656858 cites W2073852605 @default.
• W2118656858 cites W2088339753 @default.
• W2118656858 cites W2099593831 @default.
• W2118656858 cites W2099917119 @default.
• W2118656858 cites W2100270535 @default.
• W2118656858 cites W2102321716 @default.
• W2118656858 cites W2103105920 @default.
• W2118656858 cites W2106611664 @default.
• W2118656858 cites W2112461039 @default.
• W2118656858 cites W2112728975 @default.
• W2118656858 cites W2113685420 @default.
• W2118656858 cites W2114063969 @default.
• W2118656858 cites W2119394327 @default.
• W2118656858 cites W2121236256 @default.
• W2118656858 cites W2127148954 @default.
• W2118656858 cites W2128519424 @default.
• W2118656858 cites W2137033054 @default.
• W2118656858 cites W2148550388 @default.
• W2118656858 cites W2150396523 @default.
• W2118656858 cites W2150634770 @default.
• W2118656858 cites W2151680322 @default.
• W2118656858 cites W2157043395 @default.
• W2118656858 cites W2163674273 @default.
• W2118656858 cites W2165174551 @default.
• W2118656858 cites W2165704850 @default.
• W2118656858 cites W4206551354 @default.
• W2118656858 cites W4212814507 @default.
• W2118656858 cites W4237666585 @default.
• W2118656858 cites W4237709179 @default.
• W2118656858 doi "https://doi.org/10.1016/j.jnutbio.2010.04.003" @default.
• W2118656858 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/20688498" @default.
• W2118656858 hasPublicationYear "2011" @default.
• W2118656858 type Work @default.
• W2118656858 sameAs 2118656858 @default.
• W2118656858 citedByCount "30" @default.
• W2118656858 countsByYear W21186568582012 @default.
• W2118656858 countsByYear W21186568582013 @default.
• W2118656858 countsByYear W21186568582014 @default.
• W2118656858 countsByYear W21186568582015 @default.
• W2118656858 countsByYear W21186568582016 @default.
• W2118656858 countsByYear W21186568582017 @default.
• W2118656858 countsByYear W21186568582018 @default.
• W2118656858 countsByYear W21186568582019 @default.
• W2118656858 countsByYear W21186568582020 @default.
• W2118656858 countsByYear W21186568582023 @default.
• W2118656858 crossrefType "journal-article" @default.
• W2118656858 hasAuthorship W2118656858A5010285332 @default.
• W2118656858 hasAuthorship W2118656858A5011071446 @default.
• W2118656858 hasAuthorship W2118656858A5011645109 @default.
• W2118656858 hasAuthorship W2118656858A5021978850 @default.
• W2118656858 hasAuthorship W2118656858A5029854453 @default.
• W2118656858 hasAuthorship W2118656858A5030130509 @default.
• W2118656858 hasAuthorship W2118656858A5036804726 @default.
• W2118656858 hasAuthorship W2118656858A5041241937 @default.
• W2118656858 hasAuthorship W2118656858A5066215372 @default.

• next