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- W2118664900 endingPage "922" @default.
- W2118664900 startingPage "909" @default.
- W2118664900 abstract "Background: The contribution of intestine to the magnitude of drug–drug interactions (DDI) may be significant, considering high levels of inhibitors in the gut lumen achieved during absorption and the abundance of metabolic enzymes in the mature enterocytes. Intestinal inhibition is incorporated in the DDI prediction models as the ratio of the intestinal wall availability in the presence and absence of the inhibitor (FG′ and FG, respectively). Objective: This review will focus on the ability of the current approaches to estimate the extent of intestinal DDI accurately, addressing predominantly the most abundant intestinal P450 enzyme, CYP3A4. Methods: Considering the sensitivity of the DDI prediction models to the accuracy of the FG estimates, the current study focuses on 3 different in vitro and in vivo approaches to assess this parameter. Results/conclusion: The advantages and limitations of each of FG methods are outlined. Accurate assessment of this parameter is essential for the prediction of human drug clearance and drug–drug interaction potential." @default.
- W2118664900 created "2016-06-24" @default.
- W2118664900 creator A5059236152 @default.
- W2118664900 creator A5061021795 @default.
- W2118664900 creator A5063870746 @default.
- W2118664900 date "2008-07-01" @default.
- W2118664900 modified "2023-10-17" @default.
- W2118664900 title "Potential role of intestinal first-pass metabolism in the prediction of drug–drug interactions" @default.
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