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• W2118699183 abstract "ABSTRACT T-20EK is a novel fusion inhibitor designed to have enhanced α-helicity over T-20 (enfuvirtide) through engineered electrostatic interactions between glutamic acid (E) and lysine (K) substitutions. T-20EK efficiently suppresses wild-type and T-20-resistant variants. Here, we selected T-20EK-resistant variants. A combination of L33S and N43K substitutions in gp41 were required for high resistance to T-20EK. While these substitutions also caused resistance to T-20, they did not cause cross-resistance to other known fusion inhibitors." @default.
• W2118699183 created "2016-06-24" @default.
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• W2118699183 date "2013-05-20" @default.
• W2118699183 modified "2023-10-16" @default.
• W2118699183 title "HIV-1 Resistance Mechanism to an Electrostatically Constrained Peptide Fusion Inhibitor That Is Active against T-20-Resistant Strains" @default.
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• W2118699183 doi "https://doi.org/10.1128/aac.00237-13" @default.
• W2118699183 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3719727" @default.
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