FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2118702970> ?p ?o ?g. }

• W2118702970 endingPage "42" @default.
• W2118702970 startingPage "34" @default.
• W2118702970 abstract "Prostate cancer (PCa) field effect alterations provide important clues regarding the initiation of these tumors and suggest targets for prevention or biomarkers for early detection. However, biomarkers of PCa field effects that have passed independent validation are lacking, largely because these alterations are subtle and difficult to distinguish from unrelated small changes in gene expression. We hypothesized that shared expression alterations in PCa and benign prostates containing PCa (BPCs) would have a higher potential for independent validation than alterations identified in BPCs alone. Expression analyses were performed on 37 PCas and 36 unmatched BPCs and were contrasted with 28 benign prostates (BPs) from patients free of PCa. Most of the protein-coding genes and nonexonic RNAs selected according to the hypothesis were validated by quantitative RT-PCR in an independent set of 51 BPCs and BPs. A statistical model based on two markers distinguished BPCs from BPs in the RT-PCR set and in an external microarray (area under the curve = 0.84 and 0.90, respectively). In addition, genes with predominant expression in stroma were identified by expression profiling of pure stroma and epithelial cells. Pathway analysis identified dysregulated platelet-derived growth factor receptor signaling in BPC stroma. These results validate our approach for finding PCa field effect alterations and demonstrate a PCa transcriptome fingerprint in nonneoplastic cells in prostates containing cancer." @default.
• W2118702970 created "2016-06-24" @default.
• W2118702970 creator A5011416122 @default.
• W2118702970 creator A5021419381 @default.
• W2118702970 creator A5027502095 @default.
• W2118702970 creator A5050362830 @default.
• W2118702970 creator A5065393937 @default.
• W2118702970 creator A5067282152 @default.
• W2118702970 creator A5070480124 @default.
• W2118702970 creator A5082725102 @default.
• W2118702970 creator A5085479273 @default.
• W2118702970 creator A5088612087 @default.
• W2118702970 date "2012-07-01" @default.
• W2118702970 modified "2023-09-27" @default.
• W2118702970 title "Shared Gene Expression Alterations in Prostate Cancer and Histologically Benign Prostate from Patients with Prostate Cancer" @default.
• W2118702970 cites W128803419 @default.
• W2118702970 cites W1488234136 @default.
• W2118702970 cites W1510939964 @default.
• W2118702970 cites W1876024155 @default.
• W2118702970 cites W1963850841 @default.
• W2118702970 cites W1964066532 @default.
• W2118702970 cites W1964895626 @default.
• W2118702970 cites W2017359766 @default.
• W2118702970 cites W2023205876 @default.
• W2118702970 cites W2023780438 @default.
• W2118702970 cites W2036902495 @default.
• W2118702970 cites W2047443734 @default.
• W2118702970 cites W2053650456 @default.
• W2118702970 cites W2059232554 @default.
• W2118702970 cites W2069285857 @default.
• W2118702970 cites W2070618750 @default.
• W2118702970 cites W2076585749 @default.
• W2118702970 cites W2090758185 @default.
• W2118702970 cites W2095335519 @default.
• W2118702970 cites W2106948237 @default.
• W2118702970 cites W2109363337 @default.
• W2118702970 cites W2110988964 @default.
• W2118702970 cites W2138449383 @default.
• W2118702970 cites W2141188843 @default.
• W2118702970 cites W2150695488 @default.
• W2118702970 cites W2152005971 @default.
• W2118702970 cites W2160108544 @default.
• W2118702970 cites W2162511447 @default.
• W2118702970 cites W2166387306 @default.
• W2118702970 doi "https://doi.org/10.1016/j.ajpath.2012.03.043" @default.
• W2118702970 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3388167" @default.
• W2118702970 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/22640805" @default.
• W2118702970 hasPublicationYear "2012" @default.
• W2118702970 type Work @default.
• W2118702970 sameAs 2118702970 @default.
• W2118702970 citedByCount "21" @default.
• W2118702970 countsByYear W21187029702012 @default.
• W2118702970 countsByYear W21187029702013 @default.
• W2118702970 countsByYear W21187029702014 @default.
• W2118702970 countsByYear W21187029702015 @default.
• W2118702970 countsByYear W21187029702016 @default.
• W2118702970 countsByYear W21187029702017 @default.
• W2118702970 countsByYear W21187029702018 @default.
• W2118702970 countsByYear W21187029702020 @default.
• W2118702970 countsByYear W21187029702021 @default.
• W2118702970 crossrefType "journal-article" @default.
• W2118702970 hasAuthorship W2118702970A5011416122 @default.
• W2118702970 hasAuthorship W2118702970A5021419381 @default.
• W2118702970 hasAuthorship W2118702970A5027502095 @default.
• W2118702970 hasAuthorship W2118702970A5050362830 @default.
• W2118702970 hasAuthorship W2118702970A5065393937 @default.
• W2118702970 hasAuthorship W2118702970A5067282152 @default.
• W2118702970 hasAuthorship W2118702970A5070480124 @default.
• W2118702970 hasAuthorship W2118702970A5082725102 @default.
• W2118702970 hasAuthorship W2118702970A5085479273 @default.
• W2118702970 hasAuthorship W2118702970A5088612087 @default.
• W2118702970 hasBestOaLocation W21187029701 @default.
• W2118702970 hasConcept C104317684 @default.
• W2118702970 hasConcept C121608353 @default.
• W2118702970 hasConcept C142724271 @default.
• W2118702970 hasConcept C150194340 @default.
• W2118702970 hasConcept C162317418 @default.
• W2118702970 hasConcept C18431079 @default.
• W2118702970 hasConcept C186836561 @default.
• W2118702970 hasConcept C204232928 @default.
• W2118702970 hasConcept C2776235491 @default.
• W2118702970 hasConcept C2780192828 @default.
• W2118702970 hasConcept C502942594 @default.
• W2118702970 hasConcept C52124034 @default.
• W2118702970 hasConcept C54355233 @default.
• W2118702970 hasConcept C71924100 @default.
• W2118702970 hasConcept C8415881 @default.
• W2118702970 hasConcept C86803240 @default.
• W2118702970 hasConcept C87874733 @default.
• W2118702970 hasConceptScore W2118702970C104317684 @default.
• W2118702970 hasConceptScore W2118702970C121608353 @default.
• W2118702970 hasConceptScore W2118702970C142724271 @default.
• W2118702970 hasConceptScore W2118702970C150194340 @default.
• W2118702970 hasConceptScore W2118702970C162317418 @default.
• W2118702970 hasConceptScore W2118702970C18431079 @default.
• W2118702970 hasConceptScore W2118702970C186836561 @default.
• W2118702970 hasConceptScore W2118702970C204232928 @default.
• W2118702970 hasConceptScore W2118702970C2776235491 @default.

• next