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• W2118725384 abstract "Abstract Phytochemicals have provided an abundant and effective source of therapeutics for the treatment of cancer. Here we describe the characterization of a novel plant toxin, persin, with in vivo activity in the mammary gland and a p53-, estrogen receptor–, and Bcl-2-independent mode of action. Persin was previously identified from avocado leaves as the toxic principle responsible for mammary gland–specific necrosis and apoptosis in lactating livestock. Here we used a lactating mouse model to confirm that persin has a similar cytotoxicity for the lactating mammary epithelium. Further in vitro studies in a panel of human breast cancer cell lines show that persin selectively induces a G2-M cell cycle arrest and caspase-dependent apoptosis in sensitive cells. The latter is dependent on expression of the BH3-only protein Bim. Bim is a sensor of cytoskeletal integrity, and there is evidence that persin acts as a microtubule-stabilizing agent. Due to the unique structure of the compound, persin could represent a novel class of microtubule-targeting agent with potential specificity for breast cancers. [Mol Cancer Ther 2006;5(9):2300–9]" @default.
• W2118725384 created "2016-06-24" @default.
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• W2118725384 date "2006-09-01" @default.
• W2118725384 modified "2023-10-01" @default.
• W2118725384 title "A novel plant toxin, persin, with <i>in vivo</i> activity in the mammary gland, induces Bim-dependent apoptosis in human breast cancer cells" @default.
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• W2118725384 doi "https://doi.org/10.1158/1535-7163.mct-06-0170" @default.
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