FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2118728823> ?p ?o ?g. }

• W2118728823 endingPage "1162" @default.
• W2118728823 startingPage "1158" @default.
• W2118728823 abstract "Opioid abuse has been postulated as a cofactor in the immunopathogenesis of human immunodeficiency virus (HIV) infection and AIDS. We and others have recently demonstrated that opioid enhances HIV infection of human macrophages through modulation of beta-chemokines and the CCR5 receptor and that this effect is reversed by naltrexone, a tertiary opioid antagonist. Tertiary opioid antagonists cannot be used in opioid-dependent patients because they precipitate withdrawal or reversal of analgesia. We determined whether the quaternary opioid antagonist methylnaltrexone (MNTX), now in phase III clinical trials for opioid-induced constipation, reverses the opioid-mediated enhancement of HIV infection of macrophages at clinically relevant doses. MNTX completely abrogated morphine-induced HIV Bal strain infection of macrophages. MNTX also inhibited the R5 strain (ADA) envelope-pseudotyped HIV replication induced by morphine. Furthermore, MNTX abolished morphine-mediated up-regulation of CCR5 receptor expression. The ability of MNTX to block opioid-induced CCR5 expression and HIV replication at clinically relevant doses may have additional benefit for opioid abusers with HIV infection, or patients with AIDS pain receiving opioids." @default.
• W2118728823 created "2016-06-24" @default.
• W2118728823 creator A5001597949 @default.
• W2118728823 creator A5020423570 @default.
• W2118728823 creator A5040346803 @default.
• W2118728823 creator A5058719162 @default.
• W2118728823 creator A5069715775 @default.
• W2118728823 date "2003-10-14" @default.
• W2118728823 modified "2023-09-25" @default.
• W2118728823 title "Methylnaltrexone Antagonizes Opioid-Mediated Enhancement of HIV Infection of Human Blood Mononuclear Phagocytes" @default.
• W2118728823 cites W1527352542 @default.
• W2118728823 cites W1913909659 @default.
• W2118728823 cites W1966983205 @default.
• W2118728823 cites W1975933847 @default.
• W2118728823 cites W1981440980 @default.
• W2118728823 cites W1986775524 @default.
• W2118728823 cites W1987078656 @default.
• W2118728823 cites W1987755130 @default.
• W2118728823 cites W2003356209 @default.
• W2118728823 cites W2007606516 @default.
• W2118728823 cites W2017629685 @default.
• W2118728823 cites W2020960028 @default.
• W2118728823 cites W2022477506 @default.
• W2118728823 cites W2032020323 @default.
• W2118728823 cites W2042895993 @default.
• W2118728823 cites W2050716453 @default.
• W2118728823 cites W2061535566 @default.
• W2118728823 cites W2067317344 @default.
• W2118728823 cites W2069964596 @default.
• W2118728823 cites W2078030437 @default.
• W2118728823 cites W2087919519 @default.
• W2118728823 cites W2098919455 @default.
• W2118728823 cites W2112043116 @default.
• W2118728823 cites W2118983431 @default.
• W2118728823 cites W2144307265 @default.
• W2118728823 cites W2324148222 @default.
• W2118728823 cites W2415626927 @default.
• W2118728823 cites W4235783596 @default.
• W2118728823 doi "https://doi.org/10.1124/jpet.103.056697" @default.
• W2118728823 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4016816" @default.
• W2118728823 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/14560041" @default.
• W2118728823 hasPublicationYear "2003" @default.
• W2118728823 type Work @default.
• W2118728823 sameAs 2118728823 @default.
• W2118728823 citedByCount "50" @default.
• W2118728823 countsByYear W21187288232012 @default.
• W2118728823 countsByYear W21187288232013 @default.
• W2118728823 countsByYear W21187288232014 @default.
• W2118728823 countsByYear W21187288232015 @default.
• W2118728823 countsByYear W21187288232018 @default.
• W2118728823 countsByYear W21187288232019 @default.
• W2118728823 countsByYear W21187288232020 @default.
• W2118728823 countsByYear W21187288232021 @default.
• W2118728823 countsByYear W21187288232022 @default.
• W2118728823 countsByYear W21187288232023 @default.
• W2118728823 crossrefType "journal-article" @default.
• W2118728823 hasAuthorship W2118728823A5001597949 @default.
• W2118728823 hasAuthorship W2118728823A5020423570 @default.
• W2118728823 hasAuthorship W2118728823A5040346803 @default.
• W2118728823 hasAuthorship W2118728823A5058719162 @default.
• W2118728823 hasAuthorship W2118728823A5069715775 @default.
• W2118728823 hasBestOaLocation W21187288232 @default.
• W2118728823 hasConcept C126322002 @default.
• W2118728823 hasConcept C12823836 @default.
• W2118728823 hasConcept C13373296 @default.
• W2118728823 hasConcept C170493617 @default.
• W2118728823 hasConcept C203014093 @default.
• W2118728823 hasConcept C2775962371 @default.
• W2118728823 hasConcept C2776914184 @default.
• W2118728823 hasConcept C2777389121 @default.
• W2118728823 hasConcept C2777972943 @default.
• W2118728823 hasConcept C2778750930 @default.
• W2118728823 hasConcept C2779886867 @default.
• W2118728823 hasConcept C2781063702 @default.
• W2118728823 hasConcept C37044404 @default.
• W2118728823 hasConcept C71924100 @default.
• W2118728823 hasConcept C98274493 @default.
• W2118728823 hasConceptScore W2118728823C126322002 @default.
• W2118728823 hasConceptScore W2118728823C12823836 @default.
• W2118728823 hasConceptScore W2118728823C13373296 @default.
• W2118728823 hasConceptScore W2118728823C170493617 @default.
• W2118728823 hasConceptScore W2118728823C203014093 @default.
• W2118728823 hasConceptScore W2118728823C2775962371 @default.
• W2118728823 hasConceptScore W2118728823C2776914184 @default.
• W2118728823 hasConceptScore W2118728823C2777389121 @default.
• W2118728823 hasConceptScore W2118728823C2777972943 @default.
• W2118728823 hasConceptScore W2118728823C2778750930 @default.
• W2118728823 hasConceptScore W2118728823C2779886867 @default.
• W2118728823 hasConceptScore W2118728823C2781063702 @default.
• W2118728823 hasConceptScore W2118728823C37044404 @default.
• W2118728823 hasConceptScore W2118728823C71924100 @default.
• W2118728823 hasConceptScore W2118728823C98274493 @default.
• W2118728823 hasIssue "3" @default.
• W2118728823 hasLocation W21187288231 @default.
• W2118728823 hasLocation W21187288232 @default.
• W2118728823 hasLocation W21187288233 @default.
• W2118728823 hasLocation W21187288234 @default.
• W2118728823 hasOpenAccess W2118728823 @default.

• next