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- W2118730911 endingPage "8827" @default.
- W2118730911 startingPage "8806" @default.
- W2118730911 abstract "Abstract In 1919 the German chemist Hermann Staudinger was the first to describe the reaction between an azide and a phosphine. It was not until recently, however, that Bertozzi and co‐workers recognized the potential of this reaction as a method for bioconjugation and transformed it into the so‐called Staudinger ligation. The bio‐orthogonal character of both the azide and the phosphine functions has resulted in the Staudinger ligation finding numerous applications in various complex biological systems. For example, the Staudinger ligation has been utilized to label glycans, lipids, DNA, and proteins. Moreover, the Staudinger ligation has been used as a synthetic method to construct glycopeptides, microarrays, and functional biopolymers. In the emerging field of bio‐orthogonal ligation strategies, the Staudinger ligation has set a high standard to which most of the new techniques are often compared. This Review summarizes recent developments and new applications of the Staudinger ligation." @default.
- W2118730911 created "2016-06-24" @default.
- W2118730911 creator A5016767643 @default.
- W2118730911 creator A5019427579 @default.
- W2118730911 creator A5049431676 @default.
- W2118730911 date "2011-09-02" @default.
- W2118730911 modified "2023-10-18" @default.
- W2118730911 title "Staudinger Ligation as a Method for Bioconjugation" @default.
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