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- W2118731706 abstract "Engagement of CD40 on resting B cells in the presence of IL-4 triggers B cell proliferation, differentiation and homotypic adhesion. This study was designed to investigate the role of LFA-1/ICAM-1 interactions in homotypic adhesion and proliferation of CD40-activated human B lymphocytes. Freshly isolated B cells were cultured in vitro in the presence of IL-4 and of L cells expressing CD40L, the CD40 ligand. The addition to the culture medium of LFA-1 and ICAM-1 antibodies inhibited homotypic B lymphocyte adhesion. However, these antibodies failed to affect B lymphocyte proliferation and antibody production. These results indicate that aggregation and proliferation are independent events although both induced by CD40 activation." @default.
- W2118731706 created "2016-06-24" @default.
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- W2118731706 date "1996-01-01" @default.
- W2118731706 modified "2023-10-16" @default.
- W2118731706 title "Induction of LFA-1 Independent Human B Cell Proliferation and Differentiation by Binding of CD40 with its Ligand" @default.
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- W2118731706 doi "https://doi.org/10.3109/08820139609059292" @default.
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