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- W2118736830 abstract "ABSTRACT The shikimate pathway presents an attractive target for malaria chemotherapy. Three shikimic acid analogs exhibited different effects on Plasmodium falciparum growth. (6 R )-6-Fluoro-shikimate and (6 S )-6-fluoro-shikimate inhibited growth (50% inhibitory concentrations, 1.5 × 10 −5 and 2.7 × 10 −4 M, respectively), whereas 2-fluoro-shikimate had no effect. para -Aminobenzoic acid abrogated the inhibition, demonstrating that the shikimate pathway was specifically targeted." @default.
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- W2118736830 date "1999-01-01" @default.
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- W2118736830 title "Targeting the Shikimate Pathway in the Malaria Parasite <i>Plasmodium falciparum</i>" @default.
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- W2118736830 doi "https://doi.org/10.1128/aac.43.1.175" @default.
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