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• W2118744524 abstract "ABSTRACT Control of blood-borne infections is dependent on antigen-specific effector and memory T cells and high-affinity IgG responses. In chronic infections characterized by a high antigen load, it has been shown that antigen-specific T and B cells are vulnerable to downregulation and apoptosis. Anaplasma marginale is a persistent infection of cattle characterized by acute and chronic high-load bacteremia. We previously showed that CD4 + T cells primed by immunization with an A. marginale outer membrane protein were rapidly deleted following infection. Furthermore, peripheral blood T cell responses to bacteria were not observed after acute infection was controlled, suggesting dysfunctional T cell priming to other A. marginale antigens. The current study more closely investigated the kinetics of A. marginale -specific CD4 + T cell responses primed during infection. Frequent sampling of peripheral blood and spleens revealed that antigen-specific CD4 + T cell responses were first detected at 5 to 7 weeks, but the responses were sporadic and transient thereafter. A similar pattern was observed in animals sampled weekly for nearly 1 year. Paradoxically, by 2 weeks of infection, cattle had developed high titers of A. marginale -specific IgG, which remained high throughout persistent infection. This dysfunctional CD4 + T cell response to infection is consistent with continual downregulation or deletion of newly primed effector T cells, similar to what was observed for immunization-induced T cells following A. marginale infection. The failure to establish a strong memory T cell response during A. marginale infection likely contributes to bacterial persistence." @default.
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• W2118744524 date "2010-12-01" @default.
• W2118744524 modified "2023-10-16" @default.
• W2118744524 title "<i>Anaplasma marginale</i>Infection with Persistent High-Load Bacteremia Induces a Dysfunctional Memory CD4⁺T Lymphocyte Response but Sustained High IgG Titers" @default.
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• W2118744524 doi "https://doi.org/10.1128/cvi.00257-10" @default.
• W2118744524 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3008194" @default.
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