FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2118752014> ?p ?o ?g. }

• W2118752014 endingPage "6949" @default.
• W2118752014 startingPage "6936" @default.
• W2118752014 abstract "ABSTRACT GTP cyclohydrolase I (GCYH-I) is an essential Zn 2+ -dependent enzyme that catalyzes the first step of the de novo folate biosynthetic pathway in bacteria and plants, the 7-deazapurine biosynthetic pathway in Bacteria and Archaea , and the biopterin pathway in mammals. We recently reported the discovery of a new prokaryotic-specific GCYH-I (GCYH-IB) that displays no sequence identity to the canonical enzyme and is present in ∼25% of bacteria, the majority of which lack the canonical GCYH-I (renamed GCYH-IA). Genomic and genetic analyses indicate that in those organisms possessing both enzymes, e.g., Bacillus subtilis , GCYH-IA and -IB are functionally redundant, but differentially expressed. Whereas GCYH-IA is constitutively expressed, GCYH-IB is expressed only under Zn 2+ -limiting conditions. These observations are consistent with the hypothesis that GCYH-IB functions to allow folate biosynthesis during Zn 2+ starvation. Here, we present biochemical and structural data showing that bacterial GCYH-IB, like GCYH-IA, belongs to the tunneling-fold (T-fold) superfamily. However, the GCYH-IA and -IB enzymes exhibit significant differences in global structure and active-site architecture. While GCYH-IA is a unimodular, homodecameric, Zn 2+ -dependent enzyme, GCYH-IB is a bimodular, homotetrameric enzyme activated by a variety of divalent cations. The structure of GCYH-IB and the broad metal dependence exhibited by this enzyme further underscore the mechanistic plasticity that is emerging for the T-fold superfamily. Notably, while humans possess the canonical GCYH-IA enzyme, many clinically important human pathogens possess only the GCYH-IB enzyme, suggesting that this enzyme is a potential new molecular target for antibacterial development." @default.
• W2118752014 created "2016-06-24" @default.
• W2118752014 creator A5013938980 @default.
• W2118752014 creator A5016700315 @default.
• W2118752014 creator A5026856074 @default.
• W2118752014 creator A5029976904 @default.
• W2118752014 creator A5038859577 @default.
• W2118752014 creator A5041084611 @default.
• W2118752014 creator A5046381833 @default.
• W2118752014 creator A5052716602 @default.
• W2118752014 creator A5057281616 @default.
• W2118752014 creator A5071359121 @default.
• W2118752014 creator A5080737135 @default.
• W2118752014 date "2009-11-15" @default.
• W2118752014 modified "2023-10-03" @default.
• W2118752014 title "Zinc-Independent Folate Biosynthesis: Genetic, Biochemical, and Structural Investigations Reveal New Metal Dependence for GTP Cyclohydrolase IB" @default.
• W2118752014 cites W1506811553 @default.
• W2118752014 cites W1520730837 @default.
• W2118752014 cites W1539796472 @default.
• W2118752014 cites W1542656360 @default.
• W2118752014 cites W1591680814 @default.
• W2118752014 cites W1964087678 @default.
• W2118752014 cites W1968332714 @default.
• W2118752014 cites W1973247422 @default.
• W2118752014 cites W1995017064 @default.
• W2118752014 cites W1999309464 @default.
• W2118752014 cites W2001127189 @default.
• W2118752014 cites W2001641653 @default.
• W2118752014 cites W2005986251 @default.
• W2118752014 cites W2009218185 @default.
• W2118752014 cites W2016255772 @default.
• W2118752014 cites W2022058405 @default.
• W2118752014 cites W2024828265 @default.
• W2118752014 cites W2025454110 @default.
• W2118752014 cites W2026068284 @default.
• W2118752014 cites W2028487008 @default.
• W2118752014 cites W2029368474 @default.
• W2118752014 cites W2035594105 @default.
• W2118752014 cites W2038840577 @default.
• W2118752014 cites W2038859671 @default.
• W2118752014 cites W2041674796 @default.
• W2118752014 cites W2042471904 @default.
• W2118752014 cites W2043915983 @default.
• W2118752014 cites W2046409152 @default.
• W2118752014 cites W2052939618 @default.
• W2118752014 cites W2057843952 @default.
• W2118752014 cites W2059490204 @default.
• W2118752014 cites W2072284723 @default.
• W2118752014 cites W2078868084 @default.
• W2118752014 cites W2098570486 @default.
• W2118752014 cites W2100691482 @default.
• W2118752014 cites W2103797602 @default.
• W2118752014 cites W2103812049 @default.
• W2118752014 cites W2110397834 @default.
• W2118752014 cites W2112084742 @default.
• W2118752014 cites W2122327402 @default.
• W2118752014 cites W2128399345 @default.
• W2118752014 cites W2141705113 @default.
• W2118752014 cites W2143670813 @default.
• W2118752014 cites W2144081223 @default.
• W2118752014 cites W2144998676 @default.
• W2118752014 cites W2145350133 @default.
• W2118752014 cites W2150687797 @default.
• W2118752014 cites W2157177321 @default.
• W2118752014 cites W2160486532 @default.
• W2118752014 cites W2170887794 @default.
• W2118752014 cites W2176832201 @default.
• W2118752014 cites W2406567195 @default.
• W2118752014 doi "https://doi.org/10.1128/jb.00287-09" @default.
• W2118752014 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2772490" @default.
• W2118752014 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/19767425" @default.
• W2118752014 hasPublicationYear "2009" @default.
• W2118752014 type Work @default.
• W2118752014 sameAs 2118752014 @default.
• W2118752014 citedByCount "60" @default.
• W2118752014 countsByYear W21187520142012 @default.
• W2118752014 countsByYear W21187520142013 @default.
• W2118752014 countsByYear W21187520142014 @default.
• W2118752014 countsByYear W21187520142015 @default.
• W2118752014 countsByYear W21187520142016 @default.
• W2118752014 countsByYear W21187520142017 @default.
• W2118752014 countsByYear W21187520142018 @default.
• W2118752014 countsByYear W21187520142019 @default.
• W2118752014 countsByYear W21187520142020 @default.
• W2118752014 countsByYear W21187520142021 @default.
• W2118752014 countsByYear W21187520142022 @default.
• W2118752014 countsByYear W21187520142023 @default.
• W2118752014 crossrefType "journal-article" @default.
• W2118752014 hasAuthorship W2118752014A5013938980 @default.
• W2118752014 hasAuthorship W2118752014A5016700315 @default.
• W2118752014 hasAuthorship W2118752014A5026856074 @default.
• W2118752014 hasAuthorship W2118752014A5029976904 @default.
• W2118752014 hasAuthorship W2118752014A5038859577 @default.
• W2118752014 hasAuthorship W2118752014A5041084611 @default.
• W2118752014 hasAuthorship W2118752014A5046381833 @default.
• W2118752014 hasAuthorship W2118752014A5052716602 @default.
• W2118752014 hasAuthorship W2118752014A5057281616 @default.
• W2118752014 hasAuthorship W2118752014A5071359121 @default.

• next