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• W2118775322 abstract "Abstract Although CD8+ T cells are usually considered antitumoral, several recent studies report that the cells can also promote tumor progression. Using the melanoma cell line B16 as a murine model of pulmonary metastasis, we examined whether the pro- versus antitumoral effects of CD8+ T cells relate to their Ag specificity. Results of the study indicate that although CD8+ T cells specific for tumor Ags promote tumor rejection, CD8+ T cells specific for unrelated Ags promote tumor progression. We found the effect to be partly attributable to CD8+ T cells dampening effective antitumor NK cell responses. Notably, activation of CD8+ T cell responses by an unrelated stimulus, in this case infection with influenza virus, increased the number of pulmonary tumor nodules. These data provide a rationale for previously unexplained data identifying contrasting roles for CD8+ T cells in tumor progression." @default.
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• W2118775322 date "2009-12-27" @default.
• W2118775322 modified "2023-09-28" @default.
• W2118775322 title "Antigen Specificity Determines the Pro- or Antitumoral Nature of CD8+ T Cells" @default.
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• W2118775322 doi "https://doi.org/10.4049/jimmunol.0804089" @default.
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