Matches in SemOpenAlex for { <https://semopenalex.org/work/W2118778815> ?p ?o ?g. }
Showing items 1 to 84 of
84
with 100 items per page.
- W2118778815 endingPage "8" @default.
- W2118778815 startingPage "392" @default.
- W2118778815 abstract "Reported are the in vitro susceptibilities of Plasmodium falciparum to artesunate, mefloquine, quinine and chloroquine of 86 isolates and to dihydroartemisinin of 45 isolates collected from areas of high resistance to mefloquine within Thailand near the borders with Myanmar and Cambodia, and from southern Thailand where P. falciparum is generally still sensitive to mefloquine. All the isolates were highly sensitive to artesunate, but the geometric mean IC50S were higher in isolates from the Thai-Myanmar and Thai-Cambodian borders than in those from southern Thailand. The IC50S for mefloquine and artesunate were strongly correlated (Pearson r = 0.605; n = 86; P < 0.00001). As expected, the in vitro sensitivities to dihydroartemisinin and artesunate were similar and strongly correlated (at IC50, Pearson r = 0.695; n = 45; P < 0.00002). The correlation between the activity of mefloquine and artesunate requires further investigation in order to determine the potential for development of cross-resistance in nature. Our results suggest that combination with mefloquine is not the ideal way of protecting the usefulness of artemisinin and its derivatives. A search for more suitable partner drugs to these compounds and careful regulation of their use are necessary in the interest of ensuring their long therapeutic life span." @default.
- W2118778815 created "2016-06-24" @default.
- W2118778815 creator A5003744057 @default.
- W2118778815 creator A5015770695 @default.
- W2118778815 creator A5040861308 @default.
- W2118778815 creator A5051480336 @default.
- W2118778815 creator A5058079190 @default.
- W2118778815 creator A5079117537 @default.
- W2118778815 creator A5080329476 @default.
- W2118778815 date "1999-01-01" @default.
- W2118778815 modified "2023-10-14" @default.
- W2118778815 title "In vitro sensitivity of Plasmodium falciparum to artesunate in Thailand." @default.
- W2118778815 cites W1624789761 @default.
- W2118778815 cites W1651696525 @default.
- W2118778815 cites W1748160049 @default.
- W2118778815 cites W1967124792 @default.
- W2118778815 cites W1995192949 @default.
- W2118778815 cites W2030944449 @default.
- W2118778815 cites W2057962803 @default.
- W2118778815 cites W2081309321 @default.
- W2118778815 cites W2105668259 @default.
- W2118778815 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2557670" @default.
- W2118778815 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/10361756" @default.
- W2118778815 hasPublicationYear "1999" @default.
- W2118778815 type Work @default.
- W2118778815 sameAs 2118778815 @default.
- W2118778815 citedByCount "28" @default.
- W2118778815 countsByYear W21187788152012 @default.
- W2118778815 countsByYear W21187788152014 @default.
- W2118778815 crossrefType "journal-article" @default.
- W2118778815 hasAuthorship W2118778815A5003744057 @default.
- W2118778815 hasAuthorship W2118778815A5015770695 @default.
- W2118778815 hasAuthorship W2118778815A5040861308 @default.
- W2118778815 hasAuthorship W2118778815A5051480336 @default.
- W2118778815 hasAuthorship W2118778815A5058079190 @default.
- W2118778815 hasAuthorship W2118778815A5079117537 @default.
- W2118778815 hasAuthorship W2118778815A5080329476 @default.
- W2118778815 hasConcept C203014093 @default.
- W2118778815 hasConcept C2776120307 @default.
- W2118778815 hasConcept C2777199930 @default.
- W2118778815 hasConcept C2777425658 @default.
- W2118778815 hasConcept C2777617192 @default.
- W2118778815 hasConcept C2778048844 @default.
- W2118778815 hasConcept C2778059366 @default.
- W2118778815 hasConcept C2778371730 @default.
- W2118778815 hasConcept C2781160685 @default.
- W2118778815 hasConcept C556039675 @default.
- W2118778815 hasConcept C71924100 @default.
- W2118778815 hasConcept C86803240 @default.
- W2118778815 hasConcept C98274493 @default.
- W2118778815 hasConceptScore W2118778815C203014093 @default.
- W2118778815 hasConceptScore W2118778815C2776120307 @default.
- W2118778815 hasConceptScore W2118778815C2777199930 @default.
- W2118778815 hasConceptScore W2118778815C2777425658 @default.
- W2118778815 hasConceptScore W2118778815C2777617192 @default.
- W2118778815 hasConceptScore W2118778815C2778048844 @default.
- W2118778815 hasConceptScore W2118778815C2778059366 @default.
- W2118778815 hasConceptScore W2118778815C2778371730 @default.
- W2118778815 hasConceptScore W2118778815C2781160685 @default.
- W2118778815 hasConceptScore W2118778815C556039675 @default.
- W2118778815 hasConceptScore W2118778815C71924100 @default.
- W2118778815 hasConceptScore W2118778815C86803240 @default.
- W2118778815 hasConceptScore W2118778815C98274493 @default.
- W2118778815 hasIssue "5" @default.
- W2118778815 hasLocation W21187788151 @default.
- W2118778815 hasOpenAccess W2118778815 @default.
- W2118778815 hasPrimaryLocation W21187788151 @default.
- W2118778815 hasRelatedWork W113361222 @default.
- W2118778815 hasRelatedWork W2041507268 @default.
- W2118778815 hasRelatedWork W2052331461 @default.
- W2118778815 hasRelatedWork W2063725332 @default.
- W2118778815 hasRelatedWork W2118778815 @default.
- W2118778815 hasRelatedWork W2172163121 @default.
- W2118778815 hasRelatedWork W2595180937 @default.
- W2118778815 hasRelatedWork W2964860972 @default.
- W2118778815 hasRelatedWork W3125324308 @default.
- W2118778815 hasRelatedWork W3202973394 @default.
- W2118778815 hasVolume "77" @default.
- W2118778815 isParatext "false" @default.
- W2118778815 isRetracted "false" @default.
- W2118778815 magId "2118778815" @default.
- W2118778815 workType "article" @default.