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- W2118781875 abstract "▪ Abstract Chromatin boundaries and insulators are transcriptional regulatory elements that modulate interactions between enhancers and promoters and protect genes from silencing effects by the adjacent chromatin. Originally discovered in Drosophila, insulators have now been found in a variety of organisms, ranging from yeast to humans. They have been found interspersed with regulatory sequences in complex genes and at the boundaries between active and inactive chromatin. Insulators might modulate transcription by organizing the chromatin fiber within the nucleus through the establishment of higher-order domains of chromatin structure." @default.
- W2118781875 created "2016-06-24" @default.
- W2118781875 creator A5082436986 @default.
- W2118781875 creator A5088112213 @default.
- W2118781875 date "2001-12-01" @default.
- W2118781875 modified "2023-09-26" @default.
- W2118781875 title "Chromatin Insulators and Boundaries: Effects on Transcription and Nuclear Organization" @default.
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- W2118781875 doi "https://doi.org/10.1146/annurev.genet.35.102401.090349" @default.
- W2118781875 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/11700282" @default.
- W2118781875 hasPublicationYear "2001" @default.
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