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- W2118785491 abstract "X-ray crystal structures at 2.9 Å resolution are reported for two complexes of catechol diethers with HIV-1 reverse transcriptase. The results help elucidate the structural origins of the extreme antiviral activity of the compounds. The possibility of halogen bonding between the inhibitors and Pro95 is addressed. Structural analysis reveals key interactions with conserved residues P95 and W229 of importance for design of inhibitors with high potency and favorable resistance profiles." @default.
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- W2118785491 date "2012-11-19" @default.
- W2118785491 modified "2023-10-03" @default.
- W2118785491 title "Crystal Structures of HIV-1 Reverse Transcriptase with Picomolar Inhibitors Reveal Key Interactions for Drug Design" @default.
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- W2118785491 doi "https://doi.org/10.1021/ja3092642" @default.
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