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• W2118798855 abstract "To evaluate the effects of edema and elevated tissue pressure on metabolically determined blood flow, forelimb vascular resistance was determined by two techniques. Peak reactive hyperemic blood flow after release of a 5-minute arterial occlusion was bilaterally measured in the brachial arteries of 11 dogs before and after venous congestion of one limb for 4 hours at 70 mm Hg and after infusion of 1,000 ml of 6% Dextran 70. Before determining peak reactive hyperemic blood flow, congestion was released; venous pressure was then similar in both limbs. Congestion reduced peak reactive hyperemic blood flow from 23.9 ± 5.7 (SE) to 16.0 ± 3.6 ml/min 100 g -1 ( P < 0.05). Peak reactive hyperemic blood flow was unchanged in the uncongested control limb (21.2 ± 5.2 to 20.4 ± 4.5 ml/min 100 g -1 , P > 0.5) at the time when it was reduced in the congested limb. Total tissue pressure measured with a needle was greater in the congested limb (9.1 ± 1.7 mm Hg) than it was in the uncongested limb (2.5 ± 1.5 mm Hg, P < 0.01). Likewise, pressure in a chronically implanted perforated capsule was -2.1 ± 2.0 mm Hg in the control limb but was +7.2 ± 1.5 mm Hg ( P < 0.01) in the contralateral limb following congestion. Dextran 70 was infused after venous congestion; this procedure produced peak reactive hyperemic blood flows and tissue pressures which were similar in both limbs. Similarly, minimum vascular resistance following an ischemic stimulus in an isolated, denervated constant-perfused forelimb was increased from 17.7 ± 2.2 to 23.9 ± 1.8 mm Hg/ml min -1 100 g -1 ( P < 0.01) following congestion in five dogs. Brachial arterial sodium content was unchanged in four dogs following 4 hours of congestion. These data suggest that, in the presence of edema, metabolic arteriolar dilation may be impaired." @default.
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• W2118798855 date "1974-04-01" @default.
• W2118798855 modified "2023-09-26" @default.
• W2118798855 title "Influence of Experimental Edema on Metabolically Determined Blood Flow" @default.
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• W2118798855 doi "https://doi.org/10.1161/01.res.34.4.482" @default.
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