Matches in SemOpenAlex for { <https://semopenalex.org/work/W2118799314> ?p ?o ?g. }
- W2118799314 endingPage "505" @default.
- W2118799314 startingPage "496" @default.
- W2118799314 abstract "Axonal growth cones turn away from repulsive guidance cues. This may start with reduced protrusive motility in the region the growth cone leading margin that is closer to the source of repulsive cue. Using explants of E7 chick temporal retina, we examine the effects of two repulsive guidance cues, ephrin-A2 and slit3, on retinal ganglion cell growth cone protrusive activity, total F-actin, free F-actin barbed ends, and the activities (phosphorylation states) of actin regulatory proteins, ADF/cofilin and ezrin, radixin, moesin (ERM) proteins. Ephrin-A2 rapidly stops protrusive activity simultaneously with reducing F-actin, free barbed ends and the activities of ADF/cofilin and ERM proteins. Slit3 also stops protrusion and reduces the activities of ADF/cofilin and ERM proteins. We interpret these results as indicating that repulsive guidance cues inhibit actin polymerization and actin-membrane linkage to stop protrusive activity. Retrograde F-actin flow withdraws actin to the C-domain, where F-actin bundles interact with myosin II to generate contractile forces that can collapse and retract the growth cone. Our results suggest that common mechanisms are used by repulsive guidance cue to disable growth cone motility and remodel growing axon terminals." @default.
- W2118799314 created "2016-06-24" @default.
- W2118799314 creator A5033676739 @default.
- W2118799314 creator A5042094596 @default.
- W2118799314 creator A5087495220 @default.
- W2118799314 date "2012-02-24" @default.
- W2118799314 modified "2023-09-24" @default.
- W2118799314 title "Repulsive axon guidance cues ephrin-A2 and slit3 stop protrusion of the growth cone leading margin concurrently with inhibition of ADF/cofilin and ERM proteins" @default.
- W2118799314 cites W1589135618 @default.
- W2118799314 cites W1922523492 @default.
- W2118799314 cites W1963956010 @default.
- W2118799314 cites W1965959102 @default.
- W2118799314 cites W1966529319 @default.
- W2118799314 cites W1977147930 @default.
- W2118799314 cites W1977455576 @default.
- W2118799314 cites W1983745650 @default.
- W2118799314 cites W1991770248 @default.
- W2118799314 cites W1992946532 @default.
- W2118799314 cites W1997290033 @default.
- W2118799314 cites W2000522885 @default.
- W2118799314 cites W2019124470 @default.
- W2118799314 cites W2020583390 @default.
- W2118799314 cites W2023213716 @default.
- W2118799314 cites W2028283006 @default.
- W2118799314 cites W2029214232 @default.
- W2118799314 cites W2029799527 @default.
- W2118799314 cites W2031489662 @default.
- W2118799314 cites W2031506032 @default.
- W2118799314 cites W2038072169 @default.
- W2118799314 cites W2052248831 @default.
- W2118799314 cites W2052453869 @default.
- W2118799314 cites W2065331372 @default.
- W2118799314 cites W2066129746 @default.
- W2118799314 cites W2084495942 @default.
- W2118799314 cites W2086003295 @default.
- W2118799314 cites W2090996566 @default.
- W2118799314 cites W2115654943 @default.
- W2118799314 cites W2118140234 @default.
- W2118799314 cites W2121764727 @default.
- W2118799314 cites W2121854884 @default.
- W2118799314 cites W2131384342 @default.
- W2118799314 cites W2131860275 @default.
- W2118799314 cites W2133142155 @default.
- W2118799314 cites W2141551235 @default.
- W2118799314 cites W2149246707 @default.
- W2118799314 cites W2150380320 @default.
- W2118799314 cites W2159975206 @default.
- W2118799314 cites W2160262432 @default.
- W2118799314 cites W2161130983 @default.
- W2118799314 cites W2163021147 @default.
- W2118799314 cites W2164244652 @default.
- W2118799314 cites W2168869953 @default.
- W2118799314 doi "https://doi.org/10.1002/cm.21016" @default.
- W2118799314 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3380157" @default.
- W2118799314 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/22328420" @default.
- W2118799314 hasPublicationYear "2012" @default.
- W2118799314 type Work @default.
- W2118799314 sameAs 2118799314 @default.
- W2118799314 citedByCount "14" @default.
- W2118799314 countsByYear W21187993142012 @default.
- W2118799314 countsByYear W21187993142013 @default.
- W2118799314 countsByYear W21187993142014 @default.
- W2118799314 countsByYear W21187993142016 @default.
- W2118799314 countsByYear W21187993142017 @default.
- W2118799314 countsByYear W21187993142018 @default.
- W2118799314 countsByYear W21187993142022 @default.
- W2118799314 countsByYear W21187993142023 @default.
- W2118799314 crossrefType "journal-article" @default.
- W2118799314 hasAuthorship W2118799314A5033676739 @default.
- W2118799314 hasAuthorship W2118799314A5042094596 @default.
- W2118799314 hasAuthorship W2118799314A5087495220 @default.
- W2118799314 hasBestOaLocation W21187993142 @default.
- W2118799314 hasConcept C105702510 @default.
- W2118799314 hasConcept C125705527 @default.
- W2118799314 hasConcept C135903288 @default.
- W2118799314 hasConcept C142669718 @default.
- W2118799314 hasConcept C1491633281 @default.
- W2118799314 hasConcept C170286479 @default.
- W2118799314 hasConcept C2776292417 @default.
- W2118799314 hasConcept C2776601116 @default.
- W2118799314 hasConcept C2779530196 @default.
- W2118799314 hasConcept C2780246058 @default.
- W2118799314 hasConcept C2993400109 @default.
- W2118799314 hasConcept C54355233 @default.
- W2118799314 hasConcept C58207958 @default.
- W2118799314 hasConcept C62478195 @default.
- W2118799314 hasConcept C69125201 @default.
- W2118799314 hasConcept C86803240 @default.
- W2118799314 hasConcept C95444343 @default.
- W2118799314 hasConceptScore W2118799314C105702510 @default.
- W2118799314 hasConceptScore W2118799314C125705527 @default.
- W2118799314 hasConceptScore W2118799314C135903288 @default.
- W2118799314 hasConceptScore W2118799314C142669718 @default.
- W2118799314 hasConceptScore W2118799314C1491633281 @default.
- W2118799314 hasConceptScore W2118799314C170286479 @default.
- W2118799314 hasConceptScore W2118799314C2776292417 @default.
- W2118799314 hasConceptScore W2118799314C2776601116 @default.
- W2118799314 hasConceptScore W2118799314C2779530196 @default.