FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2118800477> ?p ?o ?g. }

• W2118800477 endingPage "345" @default.
• W2118800477 startingPage "336" @default.
• W2118800477 abstract "The aims of this study were to prepare novel transfersomes (TFs) for tacrolimus to treat atopic dermatitis, and to observe the therapeutic effects on mice atopic dermatitis, as compared to commercial tacrolimus ointment (Protopic®) and liposomes-gel. Different kinds of surfactants—sodium cholate, Tween 80 and Span 80 were investigated to prepare TFs respectively. TFs-Tween 80 was selected as the optimal carrier owing to the best deformability and the highest drug retentions. Entrapment efficiency and diameter were also evaluated. The optimized TFs were further made into gel and in vitro drug release of TFs-gel after 24 h was higher than the commercial ointment. Cumulative drug release from TFs-gel after 12 h in vitro was 37.6%. The optimized TFs-gel illustrated remarkably highest drug skin retentions when compared with liposomes-gel and commercial ointment in vivo skin retention experiments. The amounts of tacrolimus in epidermis and dermis from TFs-gel were 3.8 times and 4.2 times respectively as much as ointment, while liposomes-gel was only 1.7 times and 1.4 times respectively as compared to ointment. Topical application of TFs-gel displayed the best therapeutic effect on mice atopic dermatitis induced by repeated topical application of 2,4-dinitrofluorobenzene. Thus TFs displayed superior performance and effective skin target for topical delivery of tacrolimus." @default.
• W2118800477 created "2016-06-24" @default.
• W2118800477 creator A5018592491 @default.
• W2118800477 creator A5028253155 @default.
• W2118800477 creator A5055800649 @default.
• W2118800477 creator A5062065509 @default.
• W2118800477 date "2013-12-01" @default.
• W2118800477 modified "2023-10-03" @default.
• W2118800477 title "Development of tacrolimus-loaded transfersomes for deeper skin penetration enhancement and therapeutic effect improvement in vivo" @default.
• W2118800477 cites W1983985364 @default.
• W2118800477 cites W1987078254 @default.
• W2118800477 cites W1988002511 @default.
• W2118800477 cites W1988144726 @default.
• W2118800477 cites W1990107938 @default.
• W2118800477 cites W1992530456 @default.
• W2118800477 cites W1999942897 @default.
• W2118800477 cites W2006699031 @default.
• W2118800477 cites W2010167339 @default.
• W2118800477 cites W2013375216 @default.
• W2118800477 cites W2020903065 @default.
• W2118800477 cites W2023782615 @default.
• W2118800477 cites W2029383767 @default.
• W2118800477 cites W2041912496 @default.
• W2118800477 cites W2045024700 @default.
• W2118800477 cites W2047929456 @default.
• W2118800477 cites W2049388747 @default.
• W2118800477 cites W2054872615 @default.
• W2118800477 cites W2055659735 @default.
• W2118800477 cites W2057141276 @default.
• W2118800477 cites W2064382411 @default.
• W2118800477 cites W2069132375 @default.
• W2118800477 cites W2071972273 @default.
• W2118800477 cites W2073347682 @default.
• W2118800477 cites W2086050089 @default.
• W2118800477 cites W2086614286 @default.
• W2118800477 cites W2086889742 @default.
• W2118800477 cites W2089865736 @default.
• W2118800477 cites W2093525037 @default.
• W2118800477 cites W2097611806 @default.
• W2118800477 cites W2099302357 @default.
• W2118800477 cites W2104303439 @default.
• W2118800477 cites W2105987609 @default.
• W2118800477 cites W2120551915 @default.
• W2118800477 cites W2134213080 @default.
• W2118800477 cites W2144361941 @default.
• W2118800477 cites W2156209981 @default.
• W2118800477 cites W2167597191 @default.
• W2118800477 cites W260761040 @default.
• W2118800477 cites W4323772765 @default.
• W2118800477 doi "https://doi.org/10.1016/j.ajps.2013.09.005" @default.
• W2118800477 hasPublicationYear "2013" @default.
• W2118800477 type Work @default.
• W2118800477 sameAs 2118800477 @default.
• W2118800477 citedByCount "87" @default.
• W2118800477 countsByYear W21188004772014 @default.
• W2118800477 countsByYear W21188004772015 @default.
• W2118800477 countsByYear W21188004772016 @default.
• W2118800477 countsByYear W21188004772017 @default.
• W2118800477 countsByYear W21188004772018 @default.
• W2118800477 countsByYear W21188004772019 @default.
• W2118800477 countsByYear W21188004772020 @default.
• W2118800477 countsByYear W21188004772021 @default.
• W2118800477 countsByYear W21188004772022 @default.
• W2118800477 countsByYear W21188004772023 @default.
• W2118800477 crossrefType "journal-article" @default.
• W2118800477 hasAuthorship W2118800477A5018592491 @default.
• W2118800477 hasAuthorship W2118800477A5028253155 @default.
• W2118800477 hasAuthorship W2118800477A5055800649 @default.
• W2118800477 hasAuthorship W2118800477A5062065509 @default.
• W2118800477 hasBestOaLocation W21188004771 @default.
• W2118800477 hasConcept C127413603 @default.
• W2118800477 hasConcept C141071460 @default.
• W2118800477 hasConcept C142724271 @default.
• W2118800477 hasConcept C150903083 @default.
• W2118800477 hasConcept C16005928 @default.
• W2118800477 hasConcept C178790620 @default.
• W2118800477 hasConcept C185154212 @default.
• W2118800477 hasConcept C185592680 @default.
• W2118800477 hasConcept C202751555 @default.
• W2118800477 hasConcept C207001950 @default.
• W2118800477 hasConcept C2777624698 @default.
• W2118800477 hasConcept C2778329239 @default.
• W2118800477 hasConcept C2779820397 @default.
• W2118800477 hasConcept C2909675724 @default.
• W2118800477 hasConcept C2911091166 @default.
• W2118800477 hasConcept C42475967 @default.
• W2118800477 hasConcept C43617362 @default.
• W2118800477 hasConcept C55493867 @default.
• W2118800477 hasConcept C71924100 @default.
• W2118800477 hasConcept C80107235 @default.
• W2118800477 hasConcept C86803240 @default.
• W2118800477 hasConcept C98274493 @default.
• W2118800477 hasConceptScore W2118800477C127413603 @default.
• W2118800477 hasConceptScore W2118800477C141071460 @default.
• W2118800477 hasConceptScore W2118800477C142724271 @default.
• W2118800477 hasConceptScore W2118800477C150903083 @default.
• W2118800477 hasConceptScore W2118800477C16005928 @default.
• W2118800477 hasConceptScore W2118800477C178790620 @default.

• next