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• W2118835810 abstract "<h3>Objective:</h3> Detail an unusual presentation of primary CNS lymphoma presenting with cavernous sinus syndrome (CSS). <h3>Background:</h3> Typical presentation of primary CNS lymphoma include non-specific behavioral, neurocognitive, neuropsychiatric symptoms or focal neurologic signs. Such focal neurologic signs depend on the anatomic structure affected. Despite frequent ocular involvement with CNS lymphoma (20 to 25%) visual symptoms are rare (4%). CSS, even more so, as the initial manifestation in immunocompetent adults. <h3>Design/Methods:</h3> N/A <h3>Results:</h3> A 78-year-old Caucasian male in good health presented with 2 weeks of diplopia and right sided headache. Examination found right incomplete ptosis and limited elevation, depression, and adduction of the right eye with no pupillary involvement. Three months later he exhibited complete ptosis, CN VI nerve palsy, and V1/V2 nerve palsy on the right. Routine labwork was unremarkable. Viral serology and myasthenia antibody testing were negative. MRI revealed heterogeneous enhancement of the right cavernous sinus with extension to right orbital apex. LP showed slightly elevated protein level with normal cell count. Cytology and PCR of CSF were unremarkable. Transsphenoidal biopsy revealed lymphocytic inflammation but no microorganisms or malignancy. Two months later he returned with worsening vision, tremulousness, and gait imbalance. Repeat MRI showed enhancing hemorrhagic masses in the anterior right temporal lobe, T2/FLAIR hyperintense signal along the left lateral ependymal surface, and the suspected right cavernous sinus mass was unchanged. PET scan revealed increased FDG uptake of the left cerebellum and right temporal lobe and mild FDG activity of lung bases. Right anterior temporal lobectomy was performed which revealed EBV+/CD30+ diffuse large B-cell lymphoma. Patient expired post-op day 14 from persistent infection leading to respiratory failure. <h3>Conclusions:</h3> Cavernous sinus syndrome is a rare presentation of diffuse large B-cell lymphoma. The diagnosis rests heavily on imaging and biopsy results. Early diagnosis can curtail poor prognosis and with proper treatment has the potential to improve survival. <b>Disclosure:</b> Dr. Lightfoot has nothing to disclose. Dr. Sirdar has nothing to disclose." @default.
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• W2118835810 date "2012-01-01" @default.
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• W2118835810 title "A Randomized Colorectal Cancer Screening Intervention Trial in the Iowa Research Network (IRENE): Study Recruitment Methods and Baseline Results" @default.
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