Matches in SemOpenAlex for { <https://semopenalex.org/work/W2118838302> ?p ?o ?g. }
- W2118838302 abstract "There has been considerable interest in recent years in the development of therapies, which target Eph receptors or their ephrin ligands. The Eph receptor tyrosine kinases and their membrane bound ephrin ligands are cell surface molecules involved in many biological functions and cell behaviors during embryogenesis and in adult life. However, they are also expressed in an aberrant fashion on many tumors and are re-expressed on normal cells in nonmalignant pathological states. Some of the eph/ephrins including EphA7 and EphA1 protein are thought to function as tumor suppressors in particular cancers. In tumors where Eph/ephrin proteins are expressed at high levels, being expressed on the cell surface these proteins are readily accessible to antibody-mediated therapies several of which are in advanced pre-clinical or early clinical evaluation, including antibodies specific for EphA2, EphA3, and EphB4 which are expressed on many different tumors. We will review the general features of the Eph/ephrin system and discuss the role of this system in normal hematopoiesis before focusing on the role of Eph proteins in leukemia and other hematological malignancies and possible avenues for therapy." @default.
- W2118838302 created "2016-06-24" @default.
- W2118838302 creator A5048542303 @default.
- W2118838302 creator A5090491025 @default.
- W2118838302 date "2013-01-01" @default.
- W2118838302 modified "2023-09-27" @default.
- W2118838302 title "Expression and Function of the Eph Receptor Family in Leukemia and Hematopoietic Malignancies: Prospects for Targeted Therapies" @default.
- W2118838302 cites W1556791620 @default.
- W2118838302 cites W1564577788 @default.
- W2118838302 cites W1575231005 @default.
- W2118838302 cites W1576139194 @default.
- W2118838302 cites W1584018958 @default.
- W2118838302 cites W1594899067 @default.
- W2118838302 cites W1606912338 @default.
- W2118838302 cites W1808450763 @default.
- W2118838302 cites W1841871784 @default.
- W2118838302 cites W1860574331 @default.
- W2118838302 cites W1874275835 @default.
- W2118838302 cites W1876419231 @default.
- W2118838302 cites W1925841406 @default.
- W2118838302 cites W194084071 @default.
- W2118838302 cites W1947523625 @default.
- W2118838302 cites W1965680643 @default.
- W2118838302 cites W1965740748 @default.
- W2118838302 cites W1967720639 @default.
- W2118838302 cites W1967989739 @default.
- W2118838302 cites W1968656665 @default.
- W2118838302 cites W1973648086 @default.
- W2118838302 cites W1975419284 @default.
- W2118838302 cites W1976269390 @default.
- W2118838302 cites W1979385264 @default.
- W2118838302 cites W1986383569 @default.
- W2118838302 cites W1987642551 @default.
- W2118838302 cites W1992187858 @default.
- W2118838302 cites W1994137567 @default.
- W2118838302 cites W1994318749 @default.
- W2118838302 cites W1995691453 @default.
- W2118838302 cites W1997670728 @default.
- W2118838302 cites W1998077817 @default.
- W2118838302 cites W1999584573 @default.
- W2118838302 cites W2001954506 @default.
- W2118838302 cites W2002749749 @default.
- W2118838302 cites W2004328932 @default.
- W2118838302 cites W2006360922 @default.
- W2118838302 cites W2007904375 @default.
- W2118838302 cites W2012865220 @default.
- W2118838302 cites W2013070726 @default.
- W2118838302 cites W2013429578 @default.
- W2118838302 cites W2014862318 @default.
- W2118838302 cites W2016933463 @default.
- W2118838302 cites W2017020944 @default.
- W2118838302 cites W2021781936 @default.
- W2118838302 cites W2026387061 @default.
- W2118838302 cites W2029299821 @default.
- W2118838302 cites W2029441863 @default.
- W2118838302 cites W2030498911 @default.
- W2118838302 cites W2031930713 @default.
- W2118838302 cites W2033124377 @default.
- W2118838302 cites W2033968204 @default.
- W2118838302 cites W2034073392 @default.
- W2118838302 cites W2036406012 @default.
- W2118838302 cites W2040404585 @default.
- W2118838302 cites W2040574920 @default.
- W2118838302 cites W2043508733 @default.
- W2118838302 cites W2044264310 @default.
- W2118838302 cites W2048342962 @default.
- W2118838302 cites W2049380625 @default.
- W2118838302 cites W2050329907 @default.
- W2118838302 cites W2052084644 @default.
- W2118838302 cites W2052109044 @default.
- W2118838302 cites W2054744711 @default.
- W2118838302 cites W2057695445 @default.
- W2118838302 cites W2058198884 @default.
- W2118838302 cites W2059636734 @default.
- W2118838302 cites W2064867677 @default.
- W2118838302 cites W2065424213 @default.
- W2118838302 cites W2067361366 @default.
- W2118838302 cites W2070655656 @default.
- W2118838302 cites W2071002343 @default.
- W2118838302 cites W2071531299 @default.
- W2118838302 cites W2072442977 @default.
- W2118838302 cites W2074864156 @default.
- W2118838302 cites W2078785519 @default.
- W2118838302 cites W2080889566 @default.
- W2118838302 cites W2082494746 @default.
- W2118838302 cites W2082798625 @default.
- W2118838302 cites W2083158374 @default.
- W2118838302 cites W2088023367 @default.
- W2118838302 cites W2093467487 @default.
- W2118838302 cites W2094161067 @default.
- W2118838302 cites W2096653911 @default.
- W2118838302 cites W2102249975 @default.
- W2118838302 cites W2102450254 @default.
- W2118838302 cites W2105912939 @default.
- W2118838302 cites W2106008864 @default.
- W2118838302 cites W2107464678 @default.
- W2118838302 cites W2114625470 @default.
- W2118838302 cites W2118535181 @default.
- W2118838302 cites W2119355700 @default.
- W2118838302 cites W2119401631 @default.