FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2118839307> ?p ?o ?g. }

• W2118839307 endingPage "2591" @default.
• W2118839307 startingPage "2579" @default.
• W2118839307 abstract "Class XIVa myosins comprise a unique group of myosin motor proteins found in apicomplexan parasites, including those that cause malaria and toxoplasmosis. The founding member of the class XIVa family, Toxoplasma gondii myosin A (TgMyoA), is a monomeric unconventional myosin that functions at the parasite periphery to control gliding motility, host cell invasion, and host cell egress. How the motor activity of TgMyoA is regulated during these critical steps in the parasite's lytic cycle is unknown. We show here that a small-molecule enhancer of T. gondii motility and invasion (compound 130038) causes an increase in parasite intracellular calcium levels, leading to a calcium-dependent increase in TgMyoA phosphorylation. Mutation of the major sites of phosphorylation altered parasite motile behavior upon compound 130038 treatment, and parasites expressing a nonphosphorylatable mutant myosin egressed from host cells more slowly in response to treatment with calcium ionophore. These data demonstrate that TgMyoA undergoes calcium-dependent phosphorylation, which modulates myosin-driven processes in this important human pathogen." @default.
• W2118839307 created "2016-06-24" @default.
• W2118839307 creator A5000554558 @default.
• W2118839307 creator A5005237825 @default.
• W2118839307 creator A5012785451 @default.
• W2118839307 creator A5032324284 @default.
• W2118839307 creator A5049372719 @default.
• W2118839307 creator A5050393620 @default.
• W2118839307 creator A5072536880 @default.
• W2118839307 creator A5073737205 @default.
• W2118839307 date "2014-09-01" @default.
• W2118839307 modified "2023-09-28" @default.
• W2118839307 title "Calcium-dependent phosphorylation alters class XIVa myosin function in the protozoan parasite<i>Toxoplasma gondii</i>" @default.
• W2118839307 cites W1481682126 @default.
• W2118839307 cites W1798402781 @default.
• W2118839307 cites W181228338 @default.
• W2118839307 cites W1880787406 @default.
• W2118839307 cites W1925767399 @default.
• W2118839307 cites W1972179890 @default.
• W2118839307 cites W1979871423 @default.
• W2118839307 cites W1980148334 @default.
• W2118839307 cites W1983764955 @default.
• W2118839307 cites W1984347686 @default.
• W2118839307 cites W1985611492 @default.
• W2118839307 cites W1988982031 @default.
• W2118839307 cites W1990023697 @default.
• W2118839307 cites W1996338896 @default.
• W2118839307 cites W2008312450 @default.
• W2118839307 cites W2008578385 @default.
• W2118839307 cites W2009617249 @default.
• W2118839307 cites W2011065921 @default.
• W2118839307 cites W2012434248 @default.
• W2118839307 cites W2014463389 @default.
• W2118839307 cites W2015710784 @default.
• W2118839307 cites W2016023358 @default.
• W2118839307 cites W2016500542 @default.
• W2118839307 cites W2018436353 @default.
• W2118839307 cites W2020819397 @default.
• W2118839307 cites W2021894526 @default.
• W2118839307 cites W2023674706 @default.
• W2118839307 cites W2025676593 @default.
• W2118839307 cites W2029208282 @default.
• W2118839307 cites W2032703662 @default.
• W2118839307 cites W2033533051 @default.
• W2118839307 cites W2038112050 @default.
• W2118839307 cites W2039917854 @default.
• W2118839307 cites W2041057632 @default.
• W2118839307 cites W2050400429 @default.
• W2118839307 cites W2073695321 @default.
• W2118839307 cites W2074760017 @default.
• W2118839307 cites W2077116066 @default.
• W2118839307 cites W2078434652 @default.
• W2118839307 cites W2080673392 @default.
• W2118839307 cites W2083614398 @default.
• W2118839307 cites W2084281420 @default.
• W2118839307 cites W2087585115 @default.
• W2118839307 cites W2090958284 @default.
• W2118839307 cites W2091936869 @default.
• W2118839307 cites W2092943158 @default.
• W2118839307 cites W2098489572 @default.
• W2118839307 cites W2099705774 @default.
• W2118839307 cites W2109704210 @default.
• W2118839307 cites W2112017417 @default.
• W2118839307 cites W2113362939 @default.
• W2118839307 cites W2116760933 @default.
• W2118839307 cites W2120045745 @default.
• W2118839307 cites W2120265273 @default.
• W2118839307 cites W2121008880 @default.
• W2118839307 cites W2122521313 @default.
• W2118839307 cites W2126401103 @default.
• W2118839307 cites W2138439665 @default.
• W2118839307 cites W2139267818 @default.
• W2118839307 cites W2140990000 @default.
• W2118839307 cites W2141260882 @default.
• W2118839307 cites W2153882454 @default.
• W2118839307 cites W2156900609 @default.
• W2118839307 cites W2158987996 @default.
• W2118839307 cites W2161091558 @default.
• W2118839307 cites W2163382569 @default.
• W2118839307 cites W2165318062 @default.
• W2118839307 cites W2168908538 @default.
• W2118839307 cites W2413079099 @default.
• W2118839307 cites W2953300746 @default.
• W2118839307 cites W76690048 @default.
• W2118839307 cites W90844726 @default.
• W2118839307 doi "https://doi.org/10.1091/mbc.e13-11-0648" @default.
• W2118839307 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4148248" @default.
• W2118839307 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/24989796" @default.
• W2118839307 hasPublicationYear "2014" @default.
• W2118839307 type Work @default.
• W2118839307 sameAs 2118839307 @default.
• W2118839307 citedByCount "34" @default.
• W2118839307 countsByYear W21188393072015 @default.
• W2118839307 countsByYear W21188393072016 @default.
• W2118839307 countsByYear W21188393072017 @default.
• W2118839307 countsByYear W21188393072018 @default.
• W2118839307 countsByYear W21188393072019 @default.
• W2118839307 countsByYear W21188393072020 @default.

• next