FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2118848941> ?p ?o ?g. }

• W2118848941 endingPage "2823" @default.
• W2118848941 startingPage "2818" @default.
• W2118848941 abstract "We have developed a simple procedure to identify protein homologs in genomic databases. The program, called ORF, is based on comparisons of predicted secondary structure. Protein structure is far better conserved than amino acid sequence, and structure-based methods have been effective in exploiting this fact to find homologs, even among proteins with scant sequence identity. ORF is a secondary structure-based method that operates solely on predictions from sequence and requires no experimentally determined information about the structure. The approach is illustrated by an example: Thymidylate synthase, a highly conserved enzyme essential to thymidine biosynthesis in both prokaryotes and eukaryotes, is thought to be used by Archaea, but a corresponding gene has yet to be identified. Here, a candidate thymidylate synthase is identified as a previously unassigned open reading frame from the genome of Methanococcus jannaschii, viz., MJ0757. Using primary structure information alone, the optimally aligned sequence identity between MJ0757 and Escherichia coli thymidylate synthase is 7%, well below the threshold of sensitivity for detection by sequence-based methods." @default.
• W2118848941 created "2016-06-24" @default.
• W2118848941 creator A5058961190 @default.
• W2118848941 creator A5085464041 @default.
• W2118848941 date "1998-03-17" @default.
• W2118848941 modified "2023-09-23" @default.
• W2118848941 title "Seeking an ancient enzyme in <i>Methanococcus jannaschii</i> using <scp>orf</scp> , a program based on predicted secondary structure comparisons" @default.
• W2118848941 cites W1484217798 @default.
• W2118848941 cites W1542067597 @default.
• W2118848941 cites W1600318126 @default.
• W2118848941 cites W1896595404 @default.
• W2118848941 cites W19018813 @default.
• W2118848941 cites W1965860531 @default.
• W2118848941 cites W1965910641 @default.
• W2118848941 cites W1966041739 @default.
• W2118848941 cites W1971143006 @default.
• W2118848941 cites W1973491891 @default.
• W2118848941 cites W1984390944 @default.
• W2118848941 cites W1985818354 @default.
• W2118848941 cites W1988121996 @default.
• W2118848941 cites W2000758249 @default.
• W2118848941 cites W2002180966 @default.
• W2118848941 cites W2003751701 @default.
• W2118848941 cites W2003904306 @default.
• W2118848941 cites W2004801056 @default.
• W2118848941 cites W2018010122 @default.
• W2118848941 cites W2023790301 @default.
• W2118848941 cites W2024755629 @default.
• W2118848941 cites W2026258231 @default.
• W2118848941 cites W2029195137 @default.
• W2118848941 cites W2034822406 @default.
• W2118848941 cites W2036578954 @default.
• W2118848941 cites W2041318800 @default.
• W2118848941 cites W2045103836 @default.
• W2118848941 cites W2045608551 @default.
• W2118848941 cites W2053281575 @default.
• W2118848941 cites W2061917693 @default.
• W2118848941 cites W2071486470 @default.
• W2118848941 cites W2072122816 @default.
• W2118848941 cites W2074231493 @default.
• W2118848941 cites W2075925660 @default.
• W2118848941 cites W2084834656 @default.
• W2118848941 cites W2085223336 @default.
• W2118848941 cites W2085277871 @default.
• W2118848941 cites W2085445720 @default.
• W2118848941 cites W2085764610 @default.
• W2118848941 cites W2095513869 @default.
• W2118848941 cites W2103232873 @default.
• W2118848941 cites W2106882534 @default.
• W2118848941 cites W2122588339 @default.
• W2118848941 cites W2134043769 @default.
• W2118848941 cites W2139279375 @default.
• W2118848941 cites W2176123637 @default.
• W2118848941 cites W3047703793 @default.
• W2118848941 cites W3147254695 @default.
• W2118848941 cites W4239833500 @default.
• W2118848941 doi "https://doi.org/10.1073/pnas.95.6.2818" @default.
• W2118848941 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/19652" @default.
• W2118848941 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/9501173" @default.
• W2118848941 hasPublicationYear "1998" @default.
• W2118848941 type Work @default.
• W2118848941 sameAs 2118848941 @default.
• W2118848941 citedByCount "41" @default.
• W2118848941 countsByYear W21188489412012 @default.
• W2118848941 countsByYear W21188489412013 @default.
• W2118848941 countsByYear W21188489412014 @default.
• W2118848941 countsByYear W21188489412015 @default.
• W2118848941 countsByYear W21188489412019 @default.
• W2118848941 countsByYear W21188489412022 @default.
• W2118848941 crossrefType "journal-article" @default.
• W2118848941 hasAuthorship W2118848941A5058961190 @default.
• W2118848941 hasAuthorship W2118848941A5085464041 @default.
• W2118848941 hasBestOaLocation W21188489411 @default.
• W2118848941 hasConcept C104317684 @default.
• W2118848941 hasConcept C123321153 @default.
• W2118848941 hasConcept C141231307 @default.
• W2118848941 hasConcept C167625842 @default.
• W2118848941 hasConcept C199216141 @default.
• W2118848941 hasConcept C2776694085 @default.
• W2118848941 hasConcept C2776878370 @default.
• W2118848941 hasConcept C2778112365 @default.
• W2118848941 hasConcept C2780456651 @default.
• W2118848941 hasConcept C47289529 @default.
• W2118848941 hasConcept C54355233 @default.
• W2118848941 hasConcept C550995028 @default.
• W2118848941 hasConcept C55493867 @default.
• W2118848941 hasConcept C61053724 @default.
• W2118848941 hasConcept C62614982 @default.
• W2118848941 hasConcept C70721500 @default.
• W2118848941 hasConcept C86803240 @default.
• W2118848941 hasConcept C92825506 @default.
• W2118848941 hasConceptScore W2118848941C104317684 @default.
• W2118848941 hasConceptScore W2118848941C123321153 @default.
• W2118848941 hasConceptScore W2118848941C141231307 @default.
• W2118848941 hasConceptScore W2118848941C167625842 @default.
• W2118848941 hasConceptScore W2118848941C199216141 @default.
• W2118848941 hasConceptScore W2118848941C2776694085 @default.
• W2118848941 hasConceptScore W2118848941C2776878370 @default.

• next