FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2118851118> ?p ?o ?g. }

• W2118851118 abstract "The obvious answer to this question is: Yes. There are two reasons that a medical therapy would not be considered as of benefit to patients. The first of these is that the risks of toxicity or negative effects of a therapy outweigh the benefits. The second is that that therapy does not work: that it does not decrease the risk of negative outcome (for breast cancer that the risk of recurrence and/or death). Over the last 10 years there have been improvements in how we can assess patients for the appropriateness of chemotherapy: 1) We can better predict patients9 prognoses without therapy, 2) in a modest way we can better assess their risk for toxicity and 3)we can better predict for individual patients the relative efficacy of a therapy. Over the last decade models to that integrate classical pathologic information to better predict the prognosis of patients have been refined. An advance beyond these models is the development of multi-gene assays either dependent on evaluation of mRNA or proteins that can stratify patients into prognostic groupings. These new methods can be integrated with classical pathologic information to evaluate prognosis. Work on predicting toxicity from chemotherapy has been more modest, but have important possible application. Models exist for some chemotherapeutic regimens for predicting the risk of clinically significant neutropenia or cardiac toxicity. In some instances the risk of particularly severe toxicity to specific agents such as 5FU can be tested for. Perhaps the greatest advance during this period is the better definition of predictors of response to chemotherapy. There has been a long recognition that the estrogen receptor status can stratify patients particularly likely to benefit from chemotherapy, but new predictors are able to identify patients within ER subgroups with particular chemosensitivity. The move toward more personalized therapy is taking place with improvements in prognostic assessment of patients, their risk of toxicity, and whether specific agents will (or will not) reduce the risk of recurrence or breast cancer related death. This review will show that there are certainly are patients who can be identified who do not benefit from chemotherapy, and will in its summary examine what current treatment guidelines say on this topic Citation Information: Cancer Res 2009;69(24 Suppl):Abstract nr CS1-1." @default.
• W2118851118 created "2016-06-24" @default.
• W2118851118 creator A5080875837 @default.
• W2118851118 date "2009-12-15" @default.
• W2118851118 modified "2023-09-27" @default.
• W2118851118 title "Are There Groups of Patients Who Don't Benefit from Chemotherapy?" @default.
• W2118851118 doi "https://doi.org/10.1158/0008-5472.sabcs-09-cs1-1" @default.
• W2118851118 hasPublicationYear "2009" @default.
• W2118851118 type Work @default.
• W2118851118 sameAs 2118851118 @default.
• W2118851118 citedByCount "0" @default.
• W2118851118 crossrefType "proceedings-article" @default.
• W2118851118 hasAuthorship W2118851118A5080875837 @default.
• W2118851118 hasConcept C121608353 @default.
• W2118851118 hasConcept C126322002 @default.
• W2118851118 hasConcept C143998085 @default.
• W2118851118 hasConcept C177713679 @default.
• W2118851118 hasConcept C2776694085 @default.
• W2118851118 hasConcept C2777063308 @default.
• W2118851118 hasConcept C29730261 @default.
• W2118851118 hasConcept C530470458 @default.
• W2118851118 hasConcept C71924100 @default.
• W2118851118 hasConceptScore W2118851118C121608353 @default.
• W2118851118 hasConceptScore W2118851118C126322002 @default.
• W2118851118 hasConceptScore W2118851118C143998085 @default.
• W2118851118 hasConceptScore W2118851118C177713679 @default.
• W2118851118 hasConceptScore W2118851118C2776694085 @default.
• W2118851118 hasConceptScore W2118851118C2777063308 @default.
• W2118851118 hasConceptScore W2118851118C29730261 @default.
• W2118851118 hasConceptScore W2118851118C530470458 @default.
• W2118851118 hasConceptScore W2118851118C71924100 @default.
• W2118851118 hasLocation W21188511181 @default.
• W2118851118 hasOpenAccess W2118851118 @default.
• W2118851118 hasPrimaryLocation W21188511181 @default.
• W2118851118 hasRelatedWork W1967710768 @default.
• W2118851118 hasRelatedWork W2000921114 @default.
• W2118851118 hasRelatedWork W2003305036 @default.
• W2118851118 hasRelatedWork W2010108545 @default.
• W2118851118 hasRelatedWork W2109887943 @default.
• W2118851118 hasRelatedWork W2119312010 @default.
• W2118851118 hasRelatedWork W2124718942 @default.
• W2118851118 hasRelatedWork W2143539905 @default.
• W2118851118 hasRelatedWork W2150375803 @default.
• W2118851118 hasRelatedWork W2156619573 @default.
• W2118851118 hasRelatedWork W2157652647 @default.
• W2118851118 hasRelatedWork W2166546697 @default.
• W2118851118 hasRelatedWork W2306235773 @default.
• W2118851118 hasRelatedWork W2417058541 @default.
• W2118851118 hasRelatedWork W2417962497 @default.
• W2118851118 hasRelatedWork W2464528375 @default.
• W2118851118 hasRelatedWork W2558774493 @default.
• W2118851118 hasRelatedWork W2777961796 @default.
• W2118851118 hasRelatedWork W2886575517 @default.
• W2118851118 hasRelatedWork W2998955122 @default.
• W2118851118 isParatext "false" @default.
• W2118851118 isRetracted "false" @default.
• W2118851118 magId "2118851118" @default.
• W2118851118 workType "article" @default.