FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2118872454> ?p ?o ?g. }

• W2118872454 endingPage "15" @default.
• W2118872454 startingPage "3" @default.
• W2118872454 abstract "Muramyldipeptide (MDP), the minimum essential structure responsible for the immuno-adjuvant activity of peptidoglycan, is recognized by intracellular nuclear-binding oligomerization domain 2 (NOD2). Muramyldipeptide enhances the activities of lipopolysaccharide (LPS), but the mechanism underlying this effect is unclear. Here, we obtained evidence that intravenously injected MDP augments LPS-induced hypothermia in wild-type mice, but not in mice deficient in interleukin (IL)-1α/β and/or tumor-necrosis factor (TNF)-α. Muramyldipeptide also: (i) increased pro-IL-1β in tissues, but did not increase IL-1β in serum (since caspase-1 was not activated by MDP); (ii) downregulated the expression of suppressor of cytokine signaling 1 (SOCS1; a negative-feedback regulator of LPS-induced signaling); and (iii) augmented the LPS-induced production of TNF-α, IL-12 p40, and interferon (IFN)-γ. Moreover, by performing in vivo and in vitro experiments, we obtained evidence that macrophages were involved in these effects of MDP. These results suggest that two different mechanisms may underlie the augmenting effect of MDP: namely, stimulation of pro-IL-1β production by, and down-regulation of SOCS1 in, macrophages. We consider that this work may help to elucidate the pathogenesis of mixed bacterial infections, including septic shock and multiple organ dysfunction syndrome (MODS)." @default.
• W2118872454 created "2016-06-24" @default.
• W2118872454 creator A5018679419 @default.
• W2118872454 creator A5021251912 @default.
• W2118872454 creator A5026302691 @default.
• W2118872454 creator A5044978876 @default.
• W2118872454 creator A5052122814 @default.
• W2118872454 creator A5063997319 @default.
• W2118872454 creator A5074919264 @default.
• W2118872454 creator A5080517915 @default.
• W2118872454 date "2009-11-06" @default.
• W2118872454 modified "2023-10-17" @default.
• W2118872454 title "Muramyldipeptide augments the actions of lipopolysaccharide in mice by stimulating macrophages to produce pro-IL-1β and by down-regulation of the suppressor of cytokine signaling 1 (SOCS1)" @default.
• W2118872454 cites W1502146046 @default.
• W2118872454 cites W1504695357 @default.
• W2118872454 cites W1515596022 @default.
• W2118872454 cites W1515994079 @default.
• W2118872454 cites W1639777098 @default.
• W2118872454 cites W1770742983 @default.
• W2118872454 cites W1898962613 @default.
• W2118872454 cites W1921587687 @default.
• W2118872454 cites W1984188413 @default.
• W2118872454 cites W1993677761 @default.
• W2118872454 cites W1995744610 @default.
• W2118872454 cites W2013363382 @default.
• W2118872454 cites W2015861720 @default.
• W2118872454 cites W2019043807 @default.
• W2118872454 cites W2021887498 @default.
• W2118872454 cites W2037390096 @default.
• W2118872454 cites W2043667001 @default.
• W2118872454 cites W2044153851 @default.
• W2118872454 cites W2048000602 @default.
• W2118872454 cites W2054066112 @default.
• W2118872454 cites W2055659035 @default.
• W2118872454 cites W2060724258 @default.
• W2118872454 cites W2064616750 @default.
• W2118872454 cites W2065203554 @default.
• W2118872454 cites W2065871536 @default.
• W2118872454 cites W2075145828 @default.
• W2118872454 cites W2075516051 @default.
• W2118872454 cites W2075583035 @default.
• W2118872454 cites W2083119828 @default.
• W2118872454 cites W2086680192 @default.
• W2118872454 cites W2092576934 @default.
• W2118872454 cites W2093442991 @default.
• W2118872454 cites W2093826422 @default.
• W2118872454 cites W2096443475 @default.
• W2118872454 cites W2098379306 @default.
• W2118872454 cites W2100351464 @default.
• W2118872454 cites W2100837269 @default.
• W2118872454 cites W2104449433 @default.
• W2118872454 cites W2109466900 @default.
• W2118872454 cites W2111045447 @default.
• W2118872454 cites W2111900042 @default.
• W2118872454 cites W2114243917 @default.
• W2118872454 cites W2116127788 @default.
• W2118872454 cites W2119715606 @default.
• W2118872454 cites W2132482634 @default.
• W2118872454 cites W2136736147 @default.
• W2118872454 cites W2140906887 @default.
• W2118872454 cites W2143300196 @default.
• W2118872454 cites W2145577370 @default.
• W2118872454 cites W2155745908 @default.
• W2118872454 cites W2170605026 @default.
• W2118872454 cites W4322387790 @default.
• W2118872454 cites W4322697531 @default.
• W2118872454 doi "https://doi.org/10.1177/1753425909347508" @default.
• W2118872454 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/19897531" @default.
• W2118872454 hasPublicationYear "2009" @default.
• W2118872454 type Work @default.
• W2118872454 sameAs 2118872454 @default.
• W2118872454 citedByCount "22" @default.
• W2118872454 countsByYear W21188724542012 @default.
• W2118872454 countsByYear W21188724542013 @default.
• W2118872454 countsByYear W21188724542015 @default.
• W2118872454 countsByYear W21188724542016 @default.
• W2118872454 countsByYear W21188724542017 @default.
• W2118872454 countsByYear W21188724542018 @default.
• W2118872454 countsByYear W21188724542023 @default.
• W2118872454 crossrefType "journal-article" @default.
• W2118872454 hasAuthorship W2118872454A5018679419 @default.
• W2118872454 hasAuthorship W2118872454A5021251912 @default.
• W2118872454 hasAuthorship W2118872454A5026302691 @default.
• W2118872454 hasAuthorship W2118872454A5044978876 @default.
• W2118872454 hasAuthorship W2118872454A5052122814 @default.
• W2118872454 hasAuthorship W2118872454A5063997319 @default.
• W2118872454 hasAuthorship W2118872454A5074919264 @default.
• W2118872454 hasAuthorship W2118872454A5080517915 @default.
• W2118872454 hasBestOaLocation W21188724541 @default.
• W2118872454 hasConcept C104317684 @default.
• W2118872454 hasConcept C14077384 @default.
• W2118872454 hasConcept C179185449 @default.
• W2118872454 hasConcept C17991360 @default.
• W2118872454 hasConcept C185592680 @default.
• W2118872454 hasConcept C187316574 @default.
• W2118872454 hasConcept C202751555 @default.
• W2118872454 hasConcept C203014093 @default.
• W2118872454 hasConcept C2776444769 @default.

• next