Matches in SemOpenAlex for { <https://semopenalex.org/work/W2118873240> ?p ?o ?g. }
- W2118873240 endingPage "6770" @default.
- W2118873240 startingPage "6760" @default.
- W2118873240 abstract "Neuronal activity plays a pivotal role in shaping neuronal wiring. We investigated the role of neuronal activity in the formation of interhemispheric (callosal) axon projections in neonatal mouse visual cortex. Axonal labeling with enhanced green fluorescent protein (GFP) was used to demonstrate spatially organized pattern of callosal projections: GFP-labeled callosal axons from one hemisphere projected densely to a narrowly restricted region at the border between areas 17 and 18 in the contralateral hemisphere, in which they terminated in layers 1–3 and 5. This region- and layer-specific innervation pattern developed by postnatal day 15 (P15). To explore the role of neuronal activity of presynaptic and postsynaptic neurons in callosal connection development, an inwardly rectifying potassium channel, Kir2.1, was expressed in callosal projection neurons and their target postsynaptic neurons. Kir2.1 overexpression reduced the firing rate of cortical neurons. Kir2.1 overexpression in callosal projection neurons disturbed the growth of axons and their arbors that normally occurs between P7 and P13, whereas that in postsynaptic neurons had limited effect on the pattern of presynaptic callosal axon innervation. In addition, exogenous expression of a gain-of-function Kir2.1 mutant channel found in patients with a familial heart disease caused severe deficits in callosal axon projections. These results suggest that projection neuron activity plays a crucial role in interhemispheric connection development and that enhanced Kir2.1 activity can affect cortical wiring." @default.
- W2118873240 created "2016-06-24" @default.
- W2118873240 creator A5015084471 @default.
- W2118873240 creator A5027637898 @default.
- W2118873240 creator A5053372897 @default.
- W2118873240 date "2007-06-20" @default.
- W2118873240 modified "2023-10-14" @default.
- W2118873240 title "Evidence for Activity-Dependent Cortical Wiring: Formation of Interhemispheric Connections in Neonatal Mouse Visual Cortex Requires Projection Neuron Activity" @default.
- W2118873240 cites W1508919467 @default.
- W2118873240 cites W1562764236 @default.
- W2118873240 cites W1606470824 @default.
- W2118873240 cites W1627505132 @default.
- W2118873240 cites W1705218924 @default.
- W2118873240 cites W1891766120 @default.
- W2118873240 cites W1928481240 @default.
- W2118873240 cites W1942208524 @default.
- W2118873240 cites W1946158946 @default.
- W2118873240 cites W1963806203 @default.
- W2118873240 cites W1965888884 @default.
- W2118873240 cites W1969323692 @default.
- W2118873240 cites W1970323747 @default.
- W2118873240 cites W1970339131 @default.
- W2118873240 cites W1976823941 @default.
- W2118873240 cites W1977756287 @default.
- W2118873240 cites W1978415644 @default.
- W2118873240 cites W1981268965 @default.
- W2118873240 cites W1984233525 @default.
- W2118873240 cites W1986741678 @default.
- W2118873240 cites W1989969184 @default.
- W2118873240 cites W1991688321 @default.
- W2118873240 cites W1994469944 @default.
- W2118873240 cites W1995702769 @default.
- W2118873240 cites W1996024251 @default.
- W2118873240 cites W1998352118 @default.
- W2118873240 cites W1999132768 @default.
- W2118873240 cites W2001545481 @default.
- W2118873240 cites W2005268997 @default.
- W2118873240 cites W2006524726 @default.
- W2118873240 cites W2010379223 @default.
- W2118873240 cites W2010754740 @default.
- W2118873240 cites W2011469898 @default.
- W2118873240 cites W2012540168 @default.
- W2118873240 cites W2012711335 @default.
- W2118873240 cites W2013081099 @default.
- W2118873240 cites W2013829917 @default.
- W2118873240 cites W2021253017 @default.
- W2118873240 cites W2022996299 @default.
- W2118873240 cites W2025626596 @default.
- W2118873240 cites W2025868352 @default.
- W2118873240 cites W2029200930 @default.
- W2118873240 cites W2037594700 @default.
- W2118873240 cites W2039614265 @default.
- W2118873240 cites W2039620246 @default.
- W2118873240 cites W2039655932 @default.
- W2118873240 cites W2042021122 @default.
- W2118873240 cites W2044636785 @default.
- W2118873240 cites W2048162805 @default.
- W2118873240 cites W2051003815 @default.
- W2118873240 cites W2056342276 @default.
- W2118873240 cites W2057264936 @default.
- W2118873240 cites W2057749240 @default.
- W2118873240 cites W2057952294 @default.
- W2118873240 cites W2062212387 @default.
- W2118873240 cites W2066096950 @default.
- W2118873240 cites W2067829194 @default.
- W2118873240 cites W2070699656 @default.
- W2118873240 cites W2076163730 @default.
- W2118873240 cites W2077862802 @default.
- W2118873240 cites W2078299830 @default.
- W2118873240 cites W2079011952 @default.
- W2118873240 cites W2079740539 @default.
- W2118873240 cites W2085287004 @default.
- W2118873240 cites W2086536594 @default.
- W2118873240 cites W2089518215 @default.
- W2118873240 cites W2097661000 @default.
- W2118873240 cites W2117218508 @default.
- W2118873240 cites W2120761216 @default.
- W2118873240 cites W2121399400 @default.
- W2118873240 cites W2125864491 @default.
- W2118873240 cites W2136001493 @default.
- W2118873240 cites W2137414466 @default.
- W2118873240 cites W2138278483 @default.
- W2118873240 cites W2138302361 @default.
- W2118873240 cites W2139074300 @default.
- W2118873240 cites W2147918634 @default.
- W2118873240 cites W2152331578 @default.
- W2118873240 cites W2154122229 @default.
- W2118873240 cites W2157788198 @default.
- W2118873240 cites W2161766987 @default.
- W2118873240 cites W2168526827 @default.
- W2118873240 cites W2418905964 @default.
- W2118873240 cites W4239908405 @default.
- W2118873240 doi "https://doi.org/10.1523/jneurosci.1215-07.2007" @default.
- W2118873240 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6672694" @default.
- W2118873240 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/17581963" @default.
- W2118873240 hasPublicationYear "2007" @default.
- W2118873240 type Work @default.
- W2118873240 sameAs 2118873240 @default.