Matches in SemOpenAlex for { <https://semopenalex.org/work/W2118885493> ?p ?o ?g. }
- W2118885493 endingPage "5679" @default.
- W2118885493 startingPage "5664" @default.
- W2118885493 abstract "The development of endothelial cell precursors is essential for vasculogenesis. We screened for differentially expressed transcripts in endothelial cell precursors in developing mouse embryoid bodies. We cloned a complete cDNA encoding a protein that contains an amino-terminal signal peptide, five cysteine-rich domains, a von Willebrand D domain, and a trypsin inhibitor domain. We termed this protein BMPER (bone morphogenetic protein [BMP]-binding endothelial cell precursor-derived regulator). BMPER is specifically expressed in flk-1-positive cells and parallels the time course of flk-1 induction in these cells. In situ hybridization in mouse embryos demonstrates dorsal midline staining and staining of the aorto-gonadal-mesonephric region, which is known to host vascular precursor cells. BMPER is a secreted protein that directly interacts with BMP2, BMP4, and BMP6 and antagonizes BMP4-dependent Smad5 activation. In Xenopus embryos, ventral injection of BMPER mRNA results in axis duplication and downregulation of the expression of Xvent-1 (downstream target of Smad signaling). In an embryoid body differentiation assay, BMP4-dependent differentiation of endothelial cells in embryoid bodies is also antagonized by BMPER. Taken together, our data indicate that BMPER is a novel BMP-binding protein that is expressed by endothelial cell precursors, has BMP-antagonizing activity, and may play a role in endothelial cell differentiation by modulating local BMP activity." @default.
- W2118885493 created "2016-06-24" @default.
- W2118885493 creator A5001468756 @default.
- W2118885493 creator A5015202871 @default.
- W2118885493 creator A5030654513 @default.
- W2118885493 creator A5041553689 @default.
- W2118885493 creator A5045740121 @default.
- W2118885493 creator A5047456289 @default.
- W2118885493 creator A5067764257 @default.
- W2118885493 creator A5068807010 @default.
- W2118885493 creator A5077459772 @default.
- W2118885493 date "2003-08-01" @default.
- W2118885493 modified "2023-10-18" @default.
- W2118885493 title "BMPER, a Novel Endothelial Cell Precursor-Derived Protein, Antagonizes Bone Morphogenetic Protein Signaling and Endothelial Cell Differentiation" @default.
- W2118885493 cites W1512987131 @default.
- W2118885493 cites W1534052611 @default.
- W2118885493 cites W1576487484 @default.
- W2118885493 cites W1591850953 @default.
- W2118885493 cites W1607031549 @default.
- W2118885493 cites W1674015201 @default.
- W2118885493 cites W1842953786 @default.
- W2118885493 cites W1852654097 @default.
- W2118885493 cites W1902334072 @default.
- W2118885493 cites W1904595997 @default.
- W2118885493 cites W1937940610 @default.
- W2118885493 cites W1968822620 @default.
- W2118885493 cites W1971318940 @default.
- W2118885493 cites W1987266329 @default.
- W2118885493 cites W1990938412 @default.
- W2118885493 cites W1997089935 @default.
- W2118885493 cites W2001199318 @default.
- W2118885493 cites W2002609896 @default.
- W2118885493 cites W2009629707 @default.
- W2118885493 cites W2012168176 @default.
- W2118885493 cites W2015272152 @default.
- W2118885493 cites W2016686600 @default.
- W2118885493 cites W2018379453 @default.
- W2118885493 cites W2024279589 @default.
- W2118885493 cites W2025019677 @default.
- W2118885493 cites W2025853097 @default.
- W2118885493 cites W2028196271 @default.
- W2118885493 cites W2028442510 @default.
- W2118885493 cites W2028737492 @default.
- W2118885493 cites W2032187164 @default.
- W2118885493 cites W2033418096 @default.
- W2118885493 cites W2042982622 @default.
- W2118885493 cites W2044466245 @default.
- W2118885493 cites W2046516822 @default.
- W2118885493 cites W2047161723 @default.
- W2118885493 cites W2052478761 @default.
- W2118885493 cites W2056384897 @default.
- W2118885493 cites W2057972414 @default.
- W2118885493 cites W2071135527 @default.
- W2118885493 cites W2076033729 @default.
- W2118885493 cites W2076090563 @default.
- W2118885493 cites W2091637225 @default.
- W2118885493 cites W2093051724 @default.
- W2118885493 cites W2107141327 @default.
- W2118885493 cites W2110863171 @default.
- W2118885493 cites W2119074534 @default.
- W2118885493 cites W2125068279 @default.
- W2118885493 cites W2130662470 @default.
- W2118885493 cites W2131301194 @default.
- W2118885493 cites W2137281565 @default.
- W2118885493 cites W2138541587 @default.
- W2118885493 cites W2145471764 @default.
- W2118885493 cites W2150003713 @default.
- W2118885493 cites W2154897673 @default.
- W2118885493 cites W2159672271 @default.
- W2118885493 cites W2160802775 @default.
- W2118885493 cites W2162238950 @default.
- W2118885493 cites W2163504684 @default.
- W2118885493 cites W2165695219 @default.
- W2118885493 cites W2172131935 @default.
- W2118885493 cites W2172264076 @default.
- W2118885493 cites W2187500434 @default.
- W2118885493 cites W2294929520 @default.
- W2118885493 cites W2345023949 @default.
- W2118885493 cites W2346925206 @default.
- W2118885493 cites W239485386 @default.
- W2118885493 cites W310040591 @default.
- W2118885493 doi "https://doi.org/10.1128/mcb.23.16.5664-5679.2003" @default.
- W2118885493 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/166349" @default.
- W2118885493 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/12897139" @default.
- W2118885493 hasPublicationYear "2003" @default.
- W2118885493 type Work @default.
- W2118885493 sameAs 2118885493 @default.
- W2118885493 citedByCount "203" @default.
- W2118885493 countsByYear W21188854932012 @default.
- W2118885493 countsByYear W21188854932013 @default.
- W2118885493 countsByYear W21188854932014 @default.
- W2118885493 countsByYear W21188854932015 @default.
- W2118885493 countsByYear W21188854932016 @default.
- W2118885493 countsByYear W21188854932017 @default.
- W2118885493 countsByYear W21188854932018 @default.
- W2118885493 countsByYear W21188854932019 @default.
- W2118885493 countsByYear W21188854932020 @default.
- W2118885493 countsByYear W21188854932021 @default.