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- W2118889406 abstract "Background: Transcription factors are important in T-cell subset differentiation as well as clonal expansion and determine the polarization process towards different T cell phenotypes. Glucocorticoids are important for asthma treatment, potentially by modulating T cell differentiation. We hypothesize that the transcription factor balance could be of predictive value in the treatment of asthma. Our study aimed to profile T-cell transcription factors after 8 week GC-treatment of steroid naive asthmatic patients and to test the steroid sensitivity of Th2 versus Th1 and Treg transcription factors (TF) after a treatment period, which is known to control Th2-cell activity and improve clinical symptoms. Methods: Human CD4 + T-cells were isolated from steroid naive atopic asthmatics, prior and 8 weeks after successful inhalative GC-treatment. TF mRNA levels were determined using realtime RT-PCR. Additionally, CD4 + T-cells from healthy donors were exposed to a serial dilution of GC in the presence of Th1, Th2 or T reg –driving conditions and analyzed for gene expression after 48h. Results: After 8 week GC-treatment, RORC2, T-Bet and GATA-3 did not show significant changes, FOXP3 was slightly higher. In contrast the Th2-gene Gfi-1was significantly more highly expressed in asthma patients compared to healthy individuals and decreased significantly following GC treatment. In vitro analysis revealed that Gfi-1 is abundantly expressed in Th2-polarizing conditions in asthma and displays dose-dependent sensitivity to GCs. Conclusion: The current study shows for the first time that Gfi-1 is involved in allergic asthma and may represent a biomarker for assessing Th2-dependent disease and GC-responsiveness." @default.
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- W2118889406 date "2011-09-01" @default.
- W2118889406 modified "2023-09-27" @default.
- W2118889406 title "LSC 2011 Abstract: The influence of glucocorticoid therapy on trancription factor balance in asthma patients" @default.
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