Matches in SemOpenAlex for { <https://semopenalex.org/work/W2118889444> ?p ?o ?g. }
- W2118889444 endingPage "325" @default.
- W2118889444 startingPage "315" @default.
- W2118889444 abstract "In the last 5 years, there has been a remarkable change in our understanding of the health benefits of vitamin D. The classical actions of vitamin D as a determinant of mineral metabolism and rachitic bone disease have been expanded to include a broader role in skeletal homoeostasis and prevalent bone disorders such as osteoporosis. However, it is the nonskeletal function of vitamin D that has attracted most attention. Although pluripotent responses to vitamin D have been recognized for many years, our new perspective on nonclassical vitamin D function stems from two more recent concepts. The first is that impaired, vitamin D status is common to many populations across the globe. This has prompted studies to explore the health impact of suboptimal circulating levels of vitamin D, with association studies linking vitamin D ‘insufficiency’ to several chronic health problems including autoimmune and cardiovascular disease, hypertension and common cancers. In support of a broader role for vitamin D in human health, studies in vitro and using animal models have highlighted immunomodulatory and anticancer effects of vitamin D that appear to depend on localized activation of vitamin D. The conclusion from these reports is that many nonclassical actions of vitamin D are independent of conventional vitamin D endocrinology and are therefore more sensitive to variations in vitamin D status. The current review summarizes these developments, with specific reference to the newly identified effects of vitamin D on the immune system, but also highlights the challenges in translating these observations to clinical practice." @default.
- W2118889444 created "2016-06-24" @default.
- W2118889444 creator A5055574817 @default.
- W2118889444 date "2012-02-07" @default.
- W2118889444 modified "2023-10-14" @default.
- W2118889444 title "An update on vitamin D and human immunity" @default.
- W2118889444 cites W1551028857 @default.
- W2118889444 cites W1663317712 @default.
- W2118889444 cites W1797064712 @default.
- W2118889444 cites W1860888551 @default.
- W2118889444 cites W1866685620 @default.
- W2118889444 cites W1909439607 @default.
- W2118889444 cites W1963480180 @default.
- W2118889444 cites W1963871427 @default.
- W2118889444 cites W1964575414 @default.
- W2118889444 cites W1967520122 @default.
- W2118889444 cites W1971783341 @default.
- W2118889444 cites W1972181361 @default.
- W2118889444 cites W1973717656 @default.
- W2118889444 cites W1975254851 @default.
- W2118889444 cites W1975683491 @default.
- W2118889444 cites W1975876211 @default.
- W2118889444 cites W1976114447 @default.
- W2118889444 cites W1977598211 @default.
- W2118889444 cites W1978453476 @default.
- W2118889444 cites W1978946416 @default.
- W2118889444 cites W1981761303 @default.
- W2118889444 cites W1984382389 @default.
- W2118889444 cites W1993747054 @default.
- W2118889444 cites W1993801805 @default.
- W2118889444 cites W1994798498 @default.
- W2118889444 cites W1996287932 @default.
- W2118889444 cites W1996563641 @default.
- W2118889444 cites W2001079134 @default.
- W2118889444 cites W2005032514 @default.
- W2118889444 cites W2005936777 @default.
- W2118889444 cites W2007223760 @default.
- W2118889444 cites W2007331929 @default.
- W2118889444 cites W2007751085 @default.
- W2118889444 cites W2011544696 @default.
- W2118889444 cites W2013263056 @default.
- W2118889444 cites W2023425836 @default.
- W2118889444 cites W2023635033 @default.
- W2118889444 cites W2026637278 @default.
- W2118889444 cites W2026644677 @default.
- W2118889444 cites W2028287104 @default.
- W2118889444 cites W2029303788 @default.
- W2118889444 cites W2031501484 @default.
- W2118889444 cites W2033039566 @default.
- W2118889444 cites W2033273914 @default.
- W2118889444 cites W2033809293 @default.
- W2118889444 cites W2039423387 @default.
- W2118889444 cites W2039709829 @default.
- W2118889444 cites W2040361348 @default.
- W2118889444 cites W2044149187 @default.
- W2118889444 cites W2044361565 @default.
- W2118889444 cites W2046473453 @default.
- W2118889444 cites W2048169764 @default.
- W2118889444 cites W2052505493 @default.
- W2118889444 cites W2058052793 @default.
- W2118889444 cites W2059512911 @default.
- W2118889444 cites W2059587909 @default.
- W2118889444 cites W2061342326 @default.
- W2118889444 cites W2064257381 @default.
- W2118889444 cites W2064935896 @default.
- W2118889444 cites W2065321690 @default.
- W2118889444 cites W2065544998 @default.
- W2118889444 cites W2067839645 @default.
- W2118889444 cites W2068698172 @default.
- W2118889444 cites W2070441696 @default.
- W2118889444 cites W2073414064 @default.
- W2118889444 cites W2078403349 @default.
- W2118889444 cites W2080497308 @default.
- W2118889444 cites W2088412514 @default.
- W2118889444 cites W2093206323 @default.
- W2118889444 cites W2094792989 @default.
- W2118889444 cites W2094798795 @default.
- W2118889444 cites W2101781154 @default.
- W2118889444 cites W2102354280 @default.
- W2118889444 cites W2102405170 @default.
- W2118889444 cites W2103024679 @default.
- W2118889444 cites W2103544702 @default.
- W2118889444 cites W2103979725 @default.
- W2118889444 cites W2104265409 @default.
- W2118889444 cites W2106449126 @default.
- W2118889444 cites W2108825111 @default.
- W2118889444 cites W2109452366 @default.
- W2118889444 cites W2110618520 @default.
- W2118889444 cites W2113537333 @default.
- W2118889444 cites W2113647415 @default.
- W2118889444 cites W2116520267 @default.
- W2118889444 cites W2118149184 @default.
- W2118889444 cites W2119701569 @default.
- W2118889444 cites W2120241921 @default.
- W2118889444 cites W2121080036 @default.
- W2118889444 cites W2121212535 @default.
- W2118889444 cites W2123944413 @default.
- W2118889444 cites W2124070987 @default.