FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2118892263> ?p ?o ?g. }

• W2118892263 endingPage "5230" @default.
• W2118892263 startingPage "5224" @default.
• W2118892263 abstract "Epidemiologic studies suggest that elevated VWF levels and reduced ADAMTS13 activity in the plasma are risk factors for myocardial infarction. However, it remains unknown whether the ADAMTS13-VWF axis plays a causal role in the pathophysiology of myocardial infarction. In the present study, we tested the hypothesis that ADAMTS13 reduces VWF-mediated acute myocardial ischemia/reperfusion (I/R) injury in mice. Infarct size, neutrophil infiltration, and myocyte apoptosis in the left ventricular area were quantified after 30 minutes of ischemia and 23.5 hours of reperfusion injury. Adamts13(-/-) mice exhibited significantly larger infarcts concordant with increased neutrophil infiltration and myocyte apoptosis compared with wild-type (WT) mice. In contrast, Vwf(-/-) mice exhibited significantly reduced infarct size, neutrophil infiltration, and myocyte apoptosis compared with WT mice, suggesting a detrimental role for VWF in myocardial I/R injury. Treating WT or Adamts13(-/-) mice with neutralizing Abs to VWF significantly reduced infarct size compared with control Ig-treated mice. Finally, myocardial I/R injury in Adamts13(-/-)/Vwf(-/-) mice was similar to that in Vwf(-/-) mice, suggesting that the exacerbated myocardial I/R injury observed in the setting of ADAMTS13 deficiency is VWF dependent. These findings reveal that ADAMTS13 and VWF are causally involved in myocardial I/R injury." @default.
• W2118892263 created "2016-06-24" @default.
• W2118892263 creator A5040756693 @default.
• W2118892263 creator A5044207891 @default.
• W2118892263 creator A5068716490 @default.
• W2118892263 creator A5070640404 @default.
• W2118892263 creator A5083114594 @default.
• W2118892263 date "2012-12-20" @default.
• W2118892263 modified "2023-10-17" @default.
• W2118892263 title "ADAMTS13 deficiency exacerbates VWF-dependent acute myocardial ischemia/reperfusion injury in mice" @default.
• W2118892263 cites W1498302221 @default.
• W2118892263 cites W1539367341 @default.
• W2118892263 cites W1746115485 @default.
• W2118892263 cites W1963494914 @default.
• W2118892263 cites W1967765437 @default.
• W2118892263 cites W1968644067 @default.
• W2118892263 cites W1975771188 @default.
• W2118892263 cites W1976550277 @default.
• W2118892263 cites W1977203503 @default.
• W2118892263 cites W1978291840 @default.
• W2118892263 cites W1999364304 @default.
• W2118892263 cites W2012299366 @default.
• W2118892263 cites W2016420417 @default.
• W2118892263 cites W2020357852 @default.
• W2118892263 cites W2026458636 @default.
• W2118892263 cites W2029087704 @default.
• W2118892263 cites W2039601697 @default.
• W2118892263 cites W2040234393 @default.
• W2118892263 cites W2044505929 @default.
• W2118892263 cites W2049710061 @default.
• W2118892263 cites W2050001477 @default.
• W2118892263 cites W2051131128 @default.
• W2118892263 cites W2059836801 @default.
• W2118892263 cites W2071349367 @default.
• W2118892263 cites W2077248637 @default.
• W2118892263 cites W2077290326 @default.
• W2118892263 cites W2080085786 @default.
• W2118892263 cites W2092575722 @default.
• W2118892263 cites W2098512405 @default.
• W2118892263 cites W2104680298 @default.
• W2118892263 cites W2112791998 @default.
• W2118892263 cites W2114604545 @default.
• W2118892263 cites W2116868364 @default.
• W2118892263 cites W2119250965 @default.
• W2118892263 cites W2122536819 @default.
• W2118892263 cites W2124645509 @default.
• W2118892263 cites W2128727430 @default.
• W2118892263 cites W2129490932 @default.
• W2118892263 cites W2135981165 @default.
• W2118892263 cites W2141211759 @default.
• W2118892263 cites W2151724908 @default.
• W2118892263 cites W2152050803 @default.
• W2118892263 cites W2154956836 @default.
• W2118892263 cites W2157827945 @default.
• W2118892263 cites W2158369873 @default.
• W2118892263 cites W2162118609 @default.
• W2118892263 cites W2412954235 @default.
• W2118892263 doi "https://doi.org/10.1182/blood-2012-06-440255" @default.
• W2118892263 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3537314" @default.
• W2118892263 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/22983446" @default.
• W2118892263 hasPublicationYear "2012" @default.
• W2118892263 type Work @default.
• W2118892263 sameAs 2118892263 @default.
• W2118892263 citedByCount "79" @default.
• W2118892263 countsByYear W21188922632012 @default.
• W2118892263 countsByYear W21188922632013 @default.
• W2118892263 countsByYear W21188922632014 @default.
• W2118892263 countsByYear W21188922632015 @default.
• W2118892263 countsByYear W21188922632016 @default.
• W2118892263 countsByYear W21188922632017 @default.
• W2118892263 countsByYear W21188922632018 @default.
• W2118892263 countsByYear W21188922632019 @default.
• W2118892263 countsByYear W21188922632020 @default.
• W2118892263 countsByYear W21188922632021 @default.
• W2118892263 countsByYear W21188922632022 @default.
• W2118892263 countsByYear W21188922632023 @default.
• W2118892263 crossrefType "journal-article" @default.
• W2118892263 hasAuthorship W2118892263A5040756693 @default.
• W2118892263 hasAuthorship W2118892263A5044207891 @default.
• W2118892263 hasAuthorship W2118892263A5068716490 @default.
• W2118892263 hasAuthorship W2118892263A5070640404 @default.
• W2118892263 hasAuthorship W2118892263A5083114594 @default.
• W2118892263 hasBestOaLocation W21188922632 @default.
• W2118892263 hasConcept C10162356 @default.
• W2118892263 hasConcept C126322002 @default.
• W2118892263 hasConcept C134018914 @default.
• W2118892263 hasConcept C164705383 @default.
• W2118892263 hasConcept C207200792 @default.
• W2118892263 hasConcept C2779394231 @default.
• W2118892263 hasConcept C2780114680 @default.
• W2118892263 hasConcept C2780921031 @default.
• W2118892263 hasConcept C500558357 @default.
• W2118892263 hasConcept C541997718 @default.
• W2118892263 hasConcept C71924100 @default.
• W2118892263 hasConcept C89560881 @default.
• W2118892263 hasConceptScore W2118892263C10162356 @default.
• W2118892263 hasConceptScore W2118892263C126322002 @default.
• W2118892263 hasConceptScore W2118892263C134018914 @default.

• next