FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2118894802> ?p ?o ?g. }

• W2118894802 endingPage "4875" @default.
• W2118894802 startingPage "4858" @default.
• W2118894802 abstract "The mechanism of action of elisidepsin (PM02734, Irvalec®) is assumed to involve membrane permeabilization via attacking lipid rafts and hydroxylated lipids. Here we investigate the role of hypoxia in the mechanism of action of elisidepsin. Culturing under hypoxic conditions increased the half-maximal inhibitory concentration and decreased the drug’s binding to almost all cell lines which was reversed by incubation of cells with 2-hydroxy palmitic acid. The expression of fatty acid 2-hydroxylase was strongly correlated with the efficiency of the drug and inversely correlated with the effect of hypoxia. Number and brightness analysis and fluorescence anisotropy experiments showed that hypoxia decreased the clustering of lipid rafts and altered the structure of the plasma membrane. Although the binding of elisidepsin to the membrane is non-cooperative, its membrane permeabilizing effect is characterized by a Hill coefficient of ~3.3. The latter finding is in agreement with elisidepsin-induced clusters of lipid raft-anchored GFP visualized by confocal microscopy. We propose that the concentration of elisidepsin needs to reach a critical level in the membrane above which elisidepsin induces the disruption of the cell membrane. Testing for tumor hypoxia or the density of hydroxylated lipids could be an interesting strategy to increase the efficiency of elisidepsin." @default.
• W2118894802 created "2016-06-24" @default.
• W2118894802 creator A5037675253 @default.
• W2118894802 creator A5043728574 @default.
• W2118894802 creator A5054077389 @default.
• W2118894802 creator A5056919449 @default.
• W2118894802 creator A5059364953 @default.
• W2118894802 creator A5077342190 @default.
• W2118894802 creator A5083934933 @default.
• W2118894802 date "2013-12-02" @default.
• W2118894802 modified "2023-10-18" @default.
• W2118894802 title "Hypoxia Reduces the Efficiency of Elisidepsin by Inhibiting Hydroxylation and Altering the Structure of Lipid Rafts" @default.
• W2118894802 cites W1617969396 @default.
• W2118894802 cites W1967299835 @default.
• W2118894802 cites W1972701314 @default.
• W2118894802 cites W1979866869 @default.
• W2118894802 cites W1980026377 @default.
• W2118894802 cites W1988181571 @default.
• W2118894802 cites W1993541750 @default.
• W2118894802 cites W1995095281 @default.
• W2118894802 cites W1998422097 @default.
• W2118894802 cites W2004902055 @default.
• W2118894802 cites W2006073788 @default.
• W2118894802 cites W2014311652 @default.
• W2118894802 cites W2015755263 @default.
• W2118894802 cites W2016189813 @default.
• W2118894802 cites W2017453518 @default.
• W2118894802 cites W2019396114 @default.
• W2118894802 cites W2027634841 @default.
• W2118894802 cites W2041021320 @default.
• W2118894802 cites W2048410358 @default.
• W2118894802 cites W2052450933 @default.
• W2118894802 cites W2058449030 @default.
• W2118894802 cites W2059498883 @default.
• W2118894802 cites W2064618031 @default.
• W2118894802 cites W2068071851 @default.
• W2118894802 cites W2083868507 @default.
• W2118894802 cites W2088240599 @default.
• W2118894802 cites W2109116257 @default.
• W2118894802 cites W2115059753 @default.
• W2118894802 cites W2118931783 @default.
• W2118894802 cites W2136596173 @default.
• W2118894802 cites W2136643063 @default.
• W2118894802 cites W2147187959 @default.
• W2118894802 cites W2167111828 @default.
• W2118894802 cites W2280410057 @default.
• W2118894802 cites W27278763 @default.
• W2118894802 cites W3023108205 @default.
• W2118894802 cites W58194909 @default.
• W2118894802 doi "https://doi.org/10.3390/md11124858" @default.
• W2118894802 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3877891" @default.
• W2118894802 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/24317474" @default.
• W2118894802 hasPublicationYear "2013" @default.
• W2118894802 type Work @default.
• W2118894802 sameAs 2118894802 @default.
• W2118894802 citedByCount "9" @default.
• W2118894802 countsByYear W21188948022015 @default.
• W2118894802 countsByYear W21188948022016 @default.
• W2118894802 countsByYear W21188948022019 @default.
• W2118894802 countsByYear W21188948022021 @default.
• W2118894802 countsByYear W21188948022022 @default.
• W2118894802 crossrefType "journal-article" @default.
• W2118894802 hasAuthorship W2118894802A5037675253 @default.
• W2118894802 hasAuthorship W2118894802A5043728574 @default.
• W2118894802 hasAuthorship W2118894802A5054077389 @default.
• W2118894802 hasAuthorship W2118894802A5056919449 @default.
• W2118894802 hasAuthorship W2118894802A5059364953 @default.
• W2118894802 hasAuthorship W2118894802A5077342190 @default.
• W2118894802 hasAuthorship W2118894802A5083934933 @default.
• W2118894802 hasBestOaLocation W21188948021 @default.
• W2118894802 hasConcept C122398194 @default.
• W2118894802 hasConcept C12554922 @default.
• W2118894802 hasConcept C15920480 @default.
• W2118894802 hasConcept C178790620 @default.
• W2118894802 hasConcept C185592680 @default.
• W2118894802 hasConcept C2778106830 @default.
• W2118894802 hasConcept C2779178360 @default.
• W2118894802 hasConcept C2780727160 @default.
• W2118894802 hasConcept C41625074 @default.
• W2118894802 hasConcept C521977710 @default.
• W2118894802 hasConcept C543025807 @default.
• W2118894802 hasConcept C55493867 @default.
• W2118894802 hasConcept C79266657 @default.
• W2118894802 hasConcept C86803240 @default.
• W2118894802 hasConcept C9132879 @default.
• W2118894802 hasConcept C95444343 @default.
• W2118894802 hasConceptScore W2118894802C122398194 @default.
• W2118894802 hasConceptScore W2118894802C12554922 @default.
• W2118894802 hasConceptScore W2118894802C15920480 @default.
• W2118894802 hasConceptScore W2118894802C178790620 @default.
• W2118894802 hasConceptScore W2118894802C185592680 @default.
• W2118894802 hasConceptScore W2118894802C2778106830 @default.
• W2118894802 hasConceptScore W2118894802C2779178360 @default.
• W2118894802 hasConceptScore W2118894802C2780727160 @default.
• W2118894802 hasConceptScore W2118894802C41625074 @default.
• W2118894802 hasConceptScore W2118894802C521977710 @default.
• W2118894802 hasConceptScore W2118894802C543025807 @default.
• W2118894802 hasConceptScore W2118894802C55493867 @default.

• next