Matches in SemOpenAlex for { <https://semopenalex.org/work/W2118895327> ?p ?o ?g. }
- W2118895327 endingPage "259" @default.
- W2118895327 startingPage "247" @default.
- W2118895327 abstract "Background: Homology-based modeling and global optimization of energy are two complementary approaches to prediction of protein structures. A combination of the two approaches is proposed in which a novel component is added to the energy and forces similarity between homologous proteins. Results: The combination was tested for two families: pancreatic hormones and homeodomains. The simulated lowest-energy structure of the pancreatic hormones is a reasonable approximation to the native fold. The lowest-energy structure of the homeodomains has 80% of the native contacts, but the helices are not packed correctly. The fourth lowest energy structure of the homeodomains has the correct helix packing (RMS 5.4 Å and 82% of the correct contacts). Optimizations of a single protein of the family yield considerably worse structures. Conclusions: Use of coupled homologous proteins in the search for the native fold is more successful than the folding of a single protein in the family." @default.
- W2118895327 created "2016-06-24" @default.
- W2118895327 creator A5010808261 @default.
- W2118895327 creator A5072753313 @default.
- W2118895327 creator A5081349407 @default.
- W2118895327 date "1997-08-01" @default.
- W2118895327 modified "2023-10-16" @default.
- W2118895327 title "Simultaneous and coupled energy optimization of homologous proteins: a new tool for structure prediction" @default.
- W2118895327 cites W1487241819 @default.
- W2118895327 cites W1582257194 @default.
- W2118895327 cites W1605425227 @default.
- W2118895327 cites W1964889579 @default.
- W2118895327 cites W1975017420 @default.
- W2118895327 cites W1976531804 @default.
- W2118895327 cites W1979046104 @default.
- W2118895327 cites W1979941306 @default.
- W2118895327 cites W1987328021 @default.
- W2118895327 cites W1991884106 @default.
- W2118895327 cites W2000908837 @default.
- W2118895327 cites W2002277489 @default.
- W2118895327 cites W2007296976 @default.
- W2118895327 cites W2007626265 @default.
- W2118895327 cites W2024060531 @default.
- W2118895327 cites W2026298819 @default.
- W2118895327 cites W2027403895 @default.
- W2118895327 cites W2027638447 @default.
- W2118895327 cites W2031452526 @default.
- W2118895327 cites W2033515558 @default.
- W2118895327 cites W2034126246 @default.
- W2118895327 cites W2040910893 @default.
- W2118895327 cites W2041189078 @default.
- W2118895327 cites W2043191562 @default.
- W2118895327 cites W2054260513 @default.
- W2118895327 cites W2056069445 @default.
- W2118895327 cites W2058110031 @default.
- W2118895327 cites W2059846299 @default.
- W2118895327 cites W2060361607 @default.
- W2118895327 cites W2060778016 @default.
- W2118895327 cites W2063239552 @default.
- W2118895327 cites W2065569912 @default.
- W2118895327 cites W2069760359 @default.
- W2118895327 cites W2069770806 @default.
- W2118895327 cites W2072325285 @default.
- W2118895327 cites W2075433094 @default.
- W2118895327 cites W2076488922 @default.
- W2118895327 cites W2078348590 @default.
- W2118895327 cites W2079042881 @default.
- W2118895327 cites W2081518109 @default.
- W2118895327 cites W2081944345 @default.
- W2118895327 cites W2091477689 @default.
- W2118895327 cites W2091582055 @default.
- W2118895327 cites W2092409871 @default.
- W2118895327 cites W2093041540 @default.
- W2118895327 cites W2099254366 @default.
- W2118895327 cites W2103047198 @default.
- W2118895327 cites W2104121136 @default.
- W2118895327 cites W2107926260 @default.
- W2118895327 cites W2117526699 @default.
- W2118895327 cites W2136567909 @default.
- W2118895327 cites W2136739161 @default.
- W2118895327 cites W2137583795 @default.
- W2118895327 cites W2148440207 @default.
- W2118895327 cites W2149443225 @default.
- W2118895327 cites W2150901257 @default.
- W2118895327 cites W2160879227 @default.
- W2118895327 cites W2162166182 @default.
- W2118895327 cites W2171546617 @default.
- W2118895327 cites W2590415 @default.
- W2118895327 cites W3098571064 @default.
- W2118895327 cites W4246356731 @default.
- W2118895327 cites W4255847514 @default.
- W2118895327 cites W967011205 @default.
- W2118895327 doi "https://doi.org/10.1016/s1359-0278(97)00033-3" @default.
- W2118895327 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/9269565" @default.
- W2118895327 hasPublicationYear "1997" @default.
- W2118895327 type Work @default.
- W2118895327 sameAs 2118895327 @default.
- W2118895327 citedByCount "17" @default.
- W2118895327 countsByYear W21188953272013 @default.
- W2118895327 countsByYear W21188953272014 @default.
- W2118895327 countsByYear W21188953272015 @default.
- W2118895327 crossrefType "journal-article" @default.
- W2118895327 hasAuthorship W2118895327A5010808261 @default.
- W2118895327 hasAuthorship W2118895327A5072753313 @default.
- W2118895327 hasAuthorship W2118895327A5081349407 @default.
- W2118895327 hasConcept C104317684 @default.
- W2118895327 hasConcept C147597530 @default.
- W2118895327 hasConcept C14961307 @default.
- W2118895327 hasConcept C169627665 @default.
- W2118895327 hasConcept C178180057 @default.
- W2118895327 hasConcept C181199279 @default.
- W2118895327 hasConcept C185592680 @default.
- W2118895327 hasConcept C186060115 @default.
- W2118895327 hasConcept C204328495 @default.
- W2118895327 hasConcept C41008148 @default.
- W2118895327 hasConcept C47701112 @default.
- W2118895327 hasConcept C55493867 @default.
- W2118895327 hasConcept C60644358 @default.