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• W2118898496 startingPage "R1149" @default.
• W2118898496 abstract "Exogenous cholecystokinin (CCK) induces early satiety when infused into humans. Whether alimentary CCK (CCK-A) receptor blockade stimulates food intake in humans is, however, uncertain. The aim of the present investigation was, therefore, to establish the effect of CCK-A receptor blockade on satiety and eating behavior in healthy volunteers. To further explore the role of endogenous CCK, the effects of the specific CCK-A receptor antagonist loxiglumide (Lox; 22 μmol · kg −1 · h −1 ) on satiety and eating behavior were investigated in healthy men and compared with saline infusions (as placebo) in a series of randomized, double-blind, placebo-controlled, crossover studies. Lox produced a slight (7%), but not significant ( P = 0.104), increase in food intake that was accompanied by a modest (10%), but significant ( P < 0.004), increase in calorie intake. Fluid ingestion was not affected by Lox. Subjects experienced more hunger and delayed fullness during Lox infusion than during saline infusion ( P < 0.05). This study provides further evidence that CCK is an endogenous physiological satiety signal acting through CCK-A receptor-mediated mechanisms. Repeated-dose studies comparing hunger and satiety responses after CCK-A receptor blockade in healthy subjects and patients with eating disorders may help clarify the possible involvement of endogenous CCK in these conditions." @default.
• W2118898496 created "2016-06-24" @default.
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• W2118898496 date "2001-04-01" @default.
• W2118898496 modified "2023-10-11" @default.
• W2118898496 title "Loxiglumide, a CCK-A receptor antagonist, stimulates calorie intake and hunger feelings in humans" @default.
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• W2118898496 doi "https://doi.org/10.1152/ajpregu.2001.280.4.r1149" @default.
• W2118898496 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/11247838" @default.
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