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- W2118899269 abstract "Appearance of systemic side effects following topical treatment with corticosteroids is well recognized. Owing to widespread use of corticosteroids for topical application, studies are needed to determine the upper limit of treatment dose by which systemic side effects can be avoided. It has previously been shown that topical treatment with clobetasol propionate (Dermovate [Britain]; no comparable US product) in doses of 18 to 268 g/wk produced abnormal cortisol levels after cosyntropin injection. Although most pronounced at higher doses, adrenal function in some cases also was impaired at doses less than 50 g/wk. 1 In this study we assessed hypothalamic-pituitary-adrenocortical (HPA) integrity during a threeweek period of topical treatment with another widely used corticosteroid, betamethasone dipropionate cream. The results showed that treatment with 50 g/wk for three weeks without occlusion did not affect HPA function. Subjects and Methods Seventeen patients (eight female, nine male), of whom eight had severe universal psoriasis" @default.
- W2118899269 created "2016-06-24" @default.
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- W2118899269 date "1979-03-01" @default.
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- W2118899269 title "Hypothalamic-Pituitary-Adrenocortical Function" @default.
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- W2118899269 doi "https://doi.org/10.1001/archderm.1979.04010030064026" @default.
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