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• W2118904250 startingPage "2735" @default.
• W2118904250 abstract "ABSTRACT One of the essential features of all pathogenic strains of Salmonella enterica is the ability to enter into nonphagocytic cells. This pathogenic property is mediated by the Salmonella pathogenicity island 1 (SPI-1)-encoded type III secretion system. Expression of components and substrates of this system is subject to complex regulatory mechanisms. These mechanisms include a number of specific and global transcriptional regulatory proteins. In this study we have compared in S. enterica serovars Typhimurium and Typhi the effect of mutations in flagellar genes on the phenotypes associated with the SPI-1 type III protein secretion system. We found that serovar Typhi strains carrying a null mutation in either of the flagellar regulatory genes flhDC or fliA were severely deficient in entry into cultured epithelial cells and macrophage cytotoxicity. This defect could not be reversed by applying a mild centrifugal force, suggesting that the effects of the mutations were not due to the absence of motility. In contrast, the same mutations had no significant effect on the ability of serovar Typhimurium to enter into cultured Henle-407 cells or to induce macrophage cell death. Consistent with these observations, we found that the mutations in the flagellar regulatory proteins significantly reduced the expression of components of the SPI-1-encoded type III system in serovar Typhi but had a marginal effect in serovar Typhimurium. Our results therefore indicate that there is an overlap between regulatory mechanisms that control flagellar and type III secretion gene expression in Salmonella serovar Typhi." @default.
• W2118904250 created "2016-06-24" @default.
• W2118904250 creator A5016995233 @default.
• W2118904250 creator A5028054054 @default.
• W2118904250 date "2000-05-01" @default.
• W2118904250 modified "2023-09-26" @default.
• W2118904250 title "The Flagellar Sigma Factor FliA (ς ²⁸ ) Regulates the Expression of <i>Salmonella</i> Genes Associated with the Centisome 63 Type III Secretion System" @default.
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• W2118904250 doi "https://doi.org/10.1128/iai.68.5.2735-2743.2000" @default.
• W2118904250 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/97482" @default.
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