FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2118906507> ?p ?o ?g. }

• W2118906507 endingPage "4998" @default.
• W2118906507 startingPage "4988" @default.
• W2118906507 abstract "In the absence of costimulating signals, B cell receptor (BCR) crosslinking on immature B cells triggers the apoptotic cell death program. In the WEHI-231 B cell lymphoma model, anti-IgM crosslinking triggers activation of caspase-7 independently of caspase-8, followed by apoptosis. Two main mechanisms for caspase-7 activation have been proposed: (i) caspase-8 recruitment to death receptors (Fas or tumour necrosis factor); and (ii) changes in mitochondrial membrane permeability and cytochrome c release, which activate caspase-9. Here we report that caspase-7 activation induced by BCR crosslinking is independent of caspase-8 and cytochrome c translocation from mitochondria to the cytosol, as well as of mitochondrial depolarization. In addition, in a cell-free system, the S-100 fraction of anti-IgM-treated WEHI-231 cells induces a caspase activation pattern different from that activated by cytochrome c and dATP. We demonstrate that calpain specifically triggers activation and processing of caspase-7 both in vitro and in vivo, and that both processes are inhibited by calpain inhibitors. Furthermore, calpain activation is associated with decreased expression levels of calpastatin, which is upregulated by CD40 ligation. These data confirm a role for calpain during BCR crosslinking, which may be critical for cell deletion by apoptosis during B cell development and activation." @default.
• W2118906507 created "2016-06-24" @default.
• W2118906507 creator A5028134280 @default.
• W2118906507 creator A5047486015 @default.
• W2118906507 creator A5051411928 @default.
• W2118906507 date "1999-09-15" @default.
• W2118906507 modified "2023-10-18" @default.
• W2118906507 title "Implication of calpain in caspase activation during B cell clonal deletion" @default.
• W2118906507 cites W1490480018 @default.
• W2118906507 cites W1522329101 @default.
• W2118906507 cites W1523373796 @default.
• W2118906507 cites W1589414012 @default.
• W2118906507 cites W1594617739 @default.
• W2118906507 cites W1887446700 @default.
• W2118906507 cites W1966539065 @default.
• W2118906507 cites W1979842763 @default.
• W2118906507 cites W1979995768 @default.
• W2118906507 cites W1981106016 @default.
• W2118906507 cites W1992637685 @default.
• W2118906507 cites W2002503549 @default.
• W2118906507 cites W2010243701 @default.
• W2118906507 cites W2013004567 @default.
• W2118906507 cites W2025100015 @default.
• W2118906507 cites W2031263707 @default.
• W2118906507 cites W2032770280 @default.
• W2118906507 cites W2044512941 @default.
• W2118906507 cites W2044745267 @default.
• W2118906507 cites W2045267492 @default.
• W2118906507 cites W2045843248 @default.
• W2118906507 cites W2049110705 @default.
• W2118906507 cites W2049740690 @default.
• W2118906507 cites W2051756088 @default.
• W2118906507 cites W2060225494 @default.
• W2118906507 cites W2072858020 @default.
• W2118906507 cites W2076807689 @default.
• W2118906507 cites W2083658751 @default.
• W2118906507 cites W2085158671 @default.
• W2118906507 cites W2087450028 @default.
• W2118906507 cites W2094134866 @default.
• W2118906507 cites W2094334993 @default.
• W2118906507 cites W2101759139 @default.
• W2118906507 cites W2106289607 @default.
• W2118906507 cites W2108131089 @default.
• W2118906507 cites W2110357545 @default.
• W2118906507 cites W2113999599 @default.
• W2118906507 cites W2117623002 @default.
• W2118906507 cites W2119683782 @default.
• W2118906507 cites W2122538814 @default.
• W2118906507 cites W2128696674 @default.
• W2118906507 cites W2130866079 @default.
• W2118906507 cites W2137835644 @default.
• W2118906507 cites W2144701362 @default.
• W2118906507 cites W2149967205 @default.
• W2118906507 cites W2150476216 @default.
• W2118906507 cites W2159650080 @default.
• W2118906507 cites W2167293805 @default.
• W2118906507 cites W2169486888 @default.
• W2118906507 cites W2235497272 @default.
• W2118906507 cites W2267906346 @default.
• W2118906507 cites W2330982448 @default.
• W2118906507 cites W2410528252 @default.
• W2118906507 cites W2416962523 @default.
• W2118906507 cites W8087046 @default.
• W2118906507 cites W2063968553 @default.
• W2118906507 doi "https://doi.org/10.1093/emboj/18.18.4988" @default.
• W2118906507 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/1171570" @default.
• W2118906507 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/10487751" @default.
• W2118906507 hasPublicationYear "1999" @default.
• W2118906507 type Work @default.
• W2118906507 sameAs 2118906507 @default.
• W2118906507 citedByCount "174" @default.
• W2118906507 countsByYear W21189065072012 @default.
• W2118906507 countsByYear W21189065072013 @default.
• W2118906507 countsByYear W21189065072014 @default.
• W2118906507 countsByYear W21189065072016 @default.
• W2118906507 countsByYear W21189065072017 @default.
• W2118906507 countsByYear W21189065072018 @default.
• W2118906507 countsByYear W21189065072019 @default.
• W2118906507 countsByYear W21189065072020 @default.
• W2118906507 countsByYear W21189065072021 @default.
• W2118906507 countsByYear W21189065072022 @default.
• W2118906507 countsByYear W21189065072023 @default.
• W2118906507 crossrefType "journal-article" @default.
• W2118906507 hasAuthorship W2118906507A5028134280 @default.
• W2118906507 hasAuthorship W2118906507A5047486015 @default.
• W2118906507 hasAuthorship W2118906507A5051411928 @default.
• W2118906507 hasBestOaLocation W21189065072 @default.
• W2118906507 hasConcept C1186008 @default.
• W2118906507 hasConcept C12519072 @default.
• W2118906507 hasConcept C153911025 @default.
• W2118906507 hasConcept C163421366 @default.
• W2118906507 hasConcept C181199279 @default.
• W2118906507 hasConcept C190283241 @default.
• W2118906507 hasConcept C2775998712 @default.
• W2118906507 hasConcept C2777488010 @default.
• W2118906507 hasConcept C28859421 @default.
• W2118906507 hasConcept C29311851 @default.
• W2118906507 hasConcept C31573885 @default.

• next