FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2118907340> ?p ?o ?g. }

• W2118907340 endingPage "366" @default.
• W2118907340 startingPage "353" @default.
• W2118907340 abstract "Aims: We report a comparative study on the mRNA expression of ErbB receptor tyrosine kinases, and in particular ERBB4 transcript variants, in two common paediatric brain tumours: medulloblastoma (MB) and pilocytic astrocytoma (PA). Methods: While the conventional real‐time quantitative polymerase chain reaction was used to measure the expression of ERRBs and ErbB4‐processing protease genes, the LightCycler fluorescence resonance energy transfer probes were specifically designed to investigate all of the known ERBB4 juxtamembrane (JM) and cytoplasmic transcript variants. Results: The overall expression of ERBBs suggests that ErbB2/ErbB4 heterodimers and ErbB4 homodimers may be major functional units of the ErbBs in MB, while ErbB2/ErbB3 heterodimers may play a more prominent role in addition to ErbB4‐containing dimers in PA. Different expression patterns of ERBB4 JM transcripts in MB, PA and normal brain were observed. The JM‐d variant was only detected in MBs, while JM‐c was present in MB and PA but was not identified in normal brain. The expression of cleavable ERBB4 transcript variants was elevated in PAs and MBs compared with normal brain, while mRNA levels of ErbB4‐processing proteases were similar in both tumour types and normal brain. This suggests that proteolytic cleavage of ErbB4 may be more common in MB and PA, which leads to signalling events divergent from those in normal brain. Conclusion: Taken together, these results suggest that ErbB4 processing and function may be altered in brain tumours, such as MB and PA, via differential expression of JM transcript variants." @default.
• W2118907340 created "2016-06-24" @default.
• W2118907340 creator A5004593954 @default.
• W2118907340 creator A5028531373 @default.
• W2118907340 creator A5050906657 @default.
• W2118907340 creator A5064456190 @default.
• W2118907340 creator A5082649403 @default.
• W2118907340 creator A5083342160 @default.
• W2118907340 date "2009-06-30" @default.
• W2118907340 modified "2023-10-16" @default.
• W2118907340 title "Real-time quantitative polymerase chain reaction (qPCR) analysis with fluorescence resonance energy transfer (FRET) probes reveals differential expression of the four<i>ERBB4</i>juxtamembrane region variants between medulloblastoma and pilocytic astrocytoma" @default.
• W2118907340 cites W1514463309 @default.
• W2118907340 cites W1522789528 @default.
• W2118907340 cites W1582187753 @default.
• W2118907340 cites W1966928253 @default.
• W2118907340 cites W1969579081 @default.
• W2118907340 cites W1974024530 @default.
• W2118907340 cites W1995242599 @default.
• W2118907340 cites W2006257247 @default.
• W2118907340 cites W2007435673 @default.
• W2118907340 cites W2014111401 @default.
• W2118907340 cites W2022816733 @default.
• W2118907340 cites W2023578257 @default.
• W2118907340 cites W2023775321 @default.
• W2118907340 cites W2024348320 @default.
• W2118907340 cites W2024651005 @default.
• W2118907340 cites W2030182984 @default.
• W2118907340 cites W2038661578 @default.
• W2118907340 cites W2040142253 @default.
• W2118907340 cites W2053673624 @default.
• W2118907340 cites W2061655178 @default.
• W2118907340 cites W2074320983 @default.
• W2118907340 cites W2075059021 @default.
• W2118907340 cites W2080384084 @default.
• W2118907340 cites W2081916198 @default.
• W2118907340 cites W2090855460 @default.
• W2118907340 cites W2092897704 @default.
• W2118907340 cites W2093440393 @default.
• W2118907340 cites W2095406033 @default.
• W2118907340 cites W2101381508 @default.
• W2118907340 cites W2104640992 @default.
• W2118907340 cites W2107616280 @default.
• W2118907340 cites W2115736838 @default.
• W2118907340 cites W2123415105 @default.
• W2118907340 cites W2131740501 @default.
• W2118907340 cites W2134541411 @default.
• W2118907340 cites W2135198700 @default.
• W2118907340 cites W2139574983 @default.
• W2118907340 cites W2140840142 @default.
• W2118907340 cites W2143651667 @default.
• W2118907340 cites W2155614211 @default.
• W2118907340 cites W2166655074 @default.
• W2118907340 cites W2323068097 @default.
• W2118907340 doi "https://doi.org/10.1111/j.1365-2990.2008.01001.x" @default.
• W2118907340 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2705759" @default.
• W2118907340 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/19017278" @default.
• W2118907340 hasPublicationYear "2009" @default.
• W2118907340 type Work @default.
• W2118907340 sameAs 2118907340 @default.
• W2118907340 citedByCount "20" @default.
• W2118907340 countsByYear W21189073402012 @default.
• W2118907340 countsByYear W21189073402013 @default.
• W2118907340 countsByYear W21189073402015 @default.
• W2118907340 countsByYear W21189073402017 @default.
• W2118907340 countsByYear W21189073402019 @default.
• W2118907340 countsByYear W21189073402020 @default.
• W2118907340 countsByYear W21189073402022 @default.
• W2118907340 crossrefType "journal-article" @default.
• W2118907340 hasAuthorship W2118907340A5004593954 @default.
• W2118907340 hasAuthorship W2118907340A5028531373 @default.
• W2118907340 hasAuthorship W2118907340A5050906657 @default.
• W2118907340 hasAuthorship W2118907340A5064456190 @default.
• W2118907340 hasAuthorship W2118907340A5082649403 @default.
• W2118907340 hasAuthorship W2118907340A5083342160 @default.
• W2118907340 hasBestOaLocation W21189073402 @default.
• W2118907340 hasConcept C101544691 @default.
• W2118907340 hasConcept C104317684 @default.
• W2118907340 hasConcept C153911025 @default.
• W2118907340 hasConcept C170493617 @default.
• W2118907340 hasConcept C2778227246 @default.
• W2118907340 hasConcept C2778880634 @default.
• W2118907340 hasConcept C2780943970 @default.
• W2118907340 hasConcept C48023723 @default.
• W2118907340 hasConcept C502942594 @default.
• W2118907340 hasConcept C54355233 @default.
• W2118907340 hasConcept C86803240 @default.
• W2118907340 hasConceptScore W2118907340C101544691 @default.
• W2118907340 hasConceptScore W2118907340C104317684 @default.
• W2118907340 hasConceptScore W2118907340C153911025 @default.
• W2118907340 hasConceptScore W2118907340C170493617 @default.
• W2118907340 hasConceptScore W2118907340C2778227246 @default.
• W2118907340 hasConceptScore W2118907340C2778880634 @default.
• W2118907340 hasConceptScore W2118907340C2780943970 @default.
• W2118907340 hasConceptScore W2118907340C48023723 @default.
• W2118907340 hasConceptScore W2118907340C502942594 @default.
• W2118907340 hasConceptScore W2118907340C54355233 @default.
• W2118907340 hasConceptScore W2118907340C86803240 @default.
• W2118907340 hasIssue "4" @default.

• next