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• W2118926077 abstract "The allele ε4 of apolipoprotein E (APOE), which is a key regulator of lipid metabolism, represents a risk factor for cardiovascular diseases and Alzheimer's disease. Despite its adverse effects, the allele is common and shows a nonrandom global distribution that is thought to be the result of evolutionary adaptation. One hypothesis proposes that the APOE ε4 allele protects against vitamin D deficiency. Here we present, for the first time, experimental and epidemiological evidence that the APOE ε4 allele is indeed associated with higher serum vitamin D [25(OH)D] levels. In APOE4 targeted replacement mice, significantly higher 25(OH)D levels were found compared with those in APOE2 and APOE3 mice (70.9 vs. 41.8 and 27.8 nM, P<0.05). Furthermore, multivariate adjusted models show a positive association of the APOE ε4 allele with 25(OH)D levels in a small collective of human subjects (n=93; P=0.072) and a general population sample (n=699; P=0.003). The novel link suggests ε4 as a modulator of vitamin D status. Although this result agrees well with evolutionary aspects, it appears contradictory with regard to chronic diseases, especially cardiovascular disease. Large prospective cohort studies are now needed to investigate the potential implications of this finding for chronic disease risks." @default.
• W2118926077 created "2016-06-24" @default.
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• W2118926077 date "2011-06-09" @default.
• W2118926077 modified "2023-10-16" @default.
• W2118926077 title "<i>APOE</i>ε<i>4</i>is associated with higher vitamin D levels in targeted replacement mice and humans" @default.
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• W2118926077 doi "https://doi.org/10.1096/fj.11-180935" @default.
• W2118926077 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/21659554" @default.
• W2118926077 hasPublicationYear "2011" @default.
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