FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2118941595> ?p ?o ?g. }

• W2118941595 endingPage "136" @default.
• W2118941595 startingPage "131" @default.
• W2118941595 abstract "Abstract Alzheimer's disease (AD) is the most common neurodegenerative disorder characterized by the accumulation of amyloid beta (Aβ) plaques and Tau‐containing neurofibrillary tangles in vulnerable brain areas. The progression of AD is well correlated with hippocampal neuron loss which highly suggests genes associated with neuron survival would be important for AD pathogenesis. According to the recent results of genome‐wide association studies (GWAS) and other reported studies, we selected two single nucleotide polymorphisms (SNPs), rs3765728 within tumor protein p73 ( P73 ), and rs34011 within fibroblast growth factor 1 ( FGF1 ), both genes were related to neuron survival. We analyzed the distribution of rs3765728 and rs34011 in 1,083 Chinese subjects including 429 unrelated sporadic AD patients and 654 unrelated age and gender‐matched control subjects. We found that the genotype distribution of rs34011 was significantly different between AD and control group (χ 2 = 9.048, df = 2, P = 0.011). Logistic regression manifested the risk of AD increased in TT genotype carriers in total subjects (Wald = 8.892, df = 1, P = 0.003, odds ratio [OR]:2.009, 95% confidence interval [95%CI]: 1.270–3.178). This effect was also found in APOE ϵ4 carrier group (Wald = 7.844, df = 1, P = 0.005, OR: 4.201, 95%CI: 1.539–11.472), suggesting the rs34011 has a synergetic effect of APOE on AD risk. However, no association was observed between rs3765728 and AD in the Han Chinese population (χ 2 = 0.431, df = 2, P = 0.806). © 2014 Wiley Periodicals, Inc." @default.
• W2118941595 created "2016-06-24" @default.
• W2118941595 creator A5002839317 @default.
• W2118941595 creator A5014088398 @default.
• W2118941595 creator A5040136142 @default.
• W2118941595 creator A5056173721 @default.
• W2118941595 creator A5056416945 @default.
• W2118941595 creator A5065162774 @default.
• W2118941595 creator A5066762784 @default.
• W2118941595 creator A5066795228 @default.
• W2118941595 date "2014-01-24" @default.
• W2118941595 modified "2023-10-16" @default.
• W2118941595 title "A variant within<i>FGF1</i>is associated with Alzheimer's disease in the Han Chinese population" @default.
• W2118941595 cites W1531240647 @default.
• W2118941595 cites W1584036575 @default.
• W2118941595 cites W1869589103 @default.
• W2118941595 cites W1944479641 @default.
• W2118941595 cites W1965844011 @default.
• W2118941595 cites W1972151895 @default.
• W2118941595 cites W1976767068 @default.
• W2118941595 cites W1996674052 @default.
• W2118941595 cites W1999493824 @default.
• W2118941595 cites W2017001590 @default.
• W2118941595 cites W2018342879 @default.
• W2118941595 cites W2030100251 @default.
• W2118941595 cites W2034497459 @default.
• W2118941595 cites W2039836112 @default.
• W2118941595 cites W2049471018 @default.
• W2118941595 cites W2053430540 @default.
• W2118941595 cites W2056221793 @default.
• W2118941595 cites W2077986315 @default.
• W2118941595 cites W2096963202 @default.
• W2118941595 cites W2111658016 @default.
• W2118941595 cites W2119662556 @default.
• W2118941595 cites W2130158832 @default.
• W2118941595 cites W2138605126 @default.
• W2118941595 cites W2150026662 @default.
• W2118941595 cites W2171530504 @default.
• W2118941595 cites W4297902500 @default.
• W2118941595 doi "https://doi.org/10.1002/ajmg.b.32205" @default.
• W2118941595 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/24464990" @default.
• W2118941595 hasPublicationYear "2014" @default.
• W2118941595 type Work @default.
• W2118941595 sameAs 2118941595 @default.
• W2118941595 citedByCount "11" @default.
• W2118941595 countsByYear W21189415952016 @default.
• W2118941595 countsByYear W21189415952017 @default.
• W2118941595 countsByYear W21189415952018 @default.
• W2118941595 countsByYear W21189415952019 @default.
• W2118941595 countsByYear W21189415952020 @default.
• W2118941595 countsByYear W21189415952022 @default.
• W2118941595 crossrefType "journal-article" @default.
• W2118941595 hasAuthorship W2118941595A5002839317 @default.
• W2118941595 hasAuthorship W2118941595A5014088398 @default.
• W2118941595 hasAuthorship W2118941595A5040136142 @default.
• W2118941595 hasAuthorship W2118941595A5056173721 @default.
• W2118941595 hasAuthorship W2118941595A5056416945 @default.
• W2118941595 hasAuthorship W2118941595A5065162774 @default.
• W2118941595 hasAuthorship W2118941595A5066762784 @default.
• W2118941595 hasAuthorship W2118941595A5066795228 @default.
• W2118941595 hasConcept C104317684 @default.
• W2118941595 hasConcept C106208931 @default.
• W2118941595 hasConcept C126322002 @default.
• W2118941595 hasConcept C134018914 @default.
• W2118941595 hasConcept C135763542 @default.
• W2118941595 hasConcept C143998085 @default.
• W2118941595 hasConcept C153209595 @default.
• W2118941595 hasConcept C156957248 @default.
• W2118941595 hasConcept C170493617 @default.
• W2118941595 hasConcept C191709040 @default.
• W2118941595 hasConcept C2779134260 @default.
• W2118941595 hasConcept C2780942790 @default.
• W2118941595 hasConcept C2908647359 @default.
• W2118941595 hasConcept C44249647 @default.
• W2118941595 hasConcept C502032728 @default.
• W2118941595 hasConcept C54355233 @default.
• W2118941595 hasConcept C57089818 @default.
• W2118941595 hasConcept C71924100 @default.
• W2118941595 hasConcept C74373430 @default.
• W2118941595 hasConcept C82867764 @default.
• W2118941595 hasConcept C86803240 @default.
• W2118941595 hasConcept C99454951 @default.
• W2118941595 hasConceptScore W2118941595C104317684 @default.
• W2118941595 hasConceptScore W2118941595C106208931 @default.
• W2118941595 hasConceptScore W2118941595C126322002 @default.
• W2118941595 hasConceptScore W2118941595C134018914 @default.
• W2118941595 hasConceptScore W2118941595C135763542 @default.
• W2118941595 hasConceptScore W2118941595C143998085 @default.
• W2118941595 hasConceptScore W2118941595C153209595 @default.
• W2118941595 hasConceptScore W2118941595C156957248 @default.
• W2118941595 hasConceptScore W2118941595C170493617 @default.
• W2118941595 hasConceptScore W2118941595C191709040 @default.
• W2118941595 hasConceptScore W2118941595C2779134260 @default.
• W2118941595 hasConceptScore W2118941595C2780942790 @default.
• W2118941595 hasConceptScore W2118941595C2908647359 @default.
• W2118941595 hasConceptScore W2118941595C44249647 @default.
• W2118941595 hasConceptScore W2118941595C502032728 @default.
• W2118941595 hasConceptScore W2118941595C54355233 @default.

• next